Detailed information of TA system TA028681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2526572..2527122
• Replicon: chromosome
• Accession: NC_019954
• Organism: Tepidanaerobacter acetatoxydans Re1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F4LTT6
• Locus tag: TEPIRE1_RS12145
• Protein ID: WP_013779452.1
• Coordinates: 2526847..2527122 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F4LTT5
• Locus tag: TEPIRE1_RS12140
• Protein ID: WP_013779451.1
• Coordinates: 2526572..2526850 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TEPIRE1_RS12110	2522575..2523048	-	474	WP_013779446.1	phage terminase small subunit P27 family	-
TEPIRE1_RS12115	2523088..2523381	-	294	WP_013779447.1	hypothetical protein	-
TEPIRE1_RS12120	2523599..2523787	-	189	WP_015295921.1	hypothetical protein	-
TEPIRE1_RS12125	2523780..2524541	-	762	WP_013779448.1	hypothetical protein	-
TEPIRE1_RS12130	2524628..2524927	-	300	WP_013779449.1	hypothetical protein	-
TEPIRE1_RS12135	2525037..2526428	-	1392	WP_013779450.1	DNA modification methylase	-
TEPIRE1_RS12140	2526572..2526850	+	279	WP_013779451.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TEPIRE1_RS12145	2526847..2527122	+	276	WP_013779452.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TEPIRE1_RS12150	2527152..2527538	-	387	WP_013779453.1	HNH endonuclease	-
TEPIRE1_RS12155	2527501..2527737	-	237	WP_013779454.1	hypothetical protein	-
TEPIRE1_RS12165	2527983..2528414	-	432	WP_013779455.1	DUF1492 domain-containing protein	-
TEPIRE1_RS12170	2528404..2528619	-	216	WP_013779456.1	hypothetical protein	-
TEPIRE1_RS12175	2528622..2529977	-	1356	WP_013779457.1	DEAD/DEAH box helicase	-
TEPIRE1_RS12180	2529974..2530252	-	279	WP_013779458.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2481450..2538024	56574

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-79)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10775.47 Da
• Isoelectric Point: 7.8830

>T28681 WP_013779452.1 NC_019954:2526847-2527122 [Tepidanaerobacter acetatoxydans Re1]
MSRQILWTTQFKKDYKLAEKRGLNITLLDDCIRMLATGEKLPPEFRDHNLSGRWSGYRECHIQPDWLLIYRIDVDNLILV
LVRTGSHSDLF

Nucleotide

• Length: 276 bp

>T28681 NC_019954:2526847-2527122 [Tepidanaerobacter acetatoxydans Re1]
ATGAGCCGCCAGATTTTGTGGACAACACAATTTAAAAAGGATTATAAGCTTGCGGAAAAACGTGGACTTAATATTACCCT
ATTAGATGATTGTATCCGCATGCTTGCAACCGGAGAAAAGTTGCCACCCGAATTCCGTGACCATAACCTTTCCGGCAGAT
GGAGTGGTTATCGTGAGTGCCATATTCAGCCTGACTGGCTTTTGATTTACCGTATTGATGTTGATAATTTAATTCTTGTT
TTAGTTCGAACCGGTAGCCATAGCGATTTGTTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10205.59 Da
• Isoelectric Point: 4.4367

>AT28681 WP_013779451.1 NC_019954:2526572-2526850 [Tepidanaerobacter acetatoxydans Re1]
MAKKTASVSFRIDADIKKQADELFAELGLNMTTAFNIFLRQSIREGRIPFDVTLNTPNAVTVAALLEAEQIANNSDAKPY
FDVEEALQELKS

Nucleotide

• Length: 279 bp

>AT28681 NC_019954:2526572-2526850 [Tepidanaerobacter acetatoxydans Re1]
TTGGCCAAAAAAACAGCTAGTGTTAGCTTTAGAATCGATGCCGATATTAAAAAACAGGCGGATGAACTGTTTGCAGAGCT
TGGACTTAATATGACTACAGCCTTCAATATTTTTCTACGCCAATCAATAAGAGAAGGACGTATTCCCTTTGATGTCACTC
TAAATACCCCTAATGCTGTGACAGTGGCCGCTCTACTTGAAGCAGAGCAAATTGCTAATAACTCAGATGCTAAACCTTAT
TTTGATGTCGAGGAAGCGCTGCAGGAGTTAAAATCATGA

Structures

Toxin

• AlphaFold DB: F4LTT6

Antitoxin

• AlphaFold DB: F4LTT5