Detailed information of TA system TA028680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3807387..3808556
• Replicon: chromosome
• Accession: NC_019940
• Organism: Thioflavicoccus mobilis 8321

Toxin (Protein)

• Gene name: -
• Uniprot ID: L0GZF2
• Locus tag: THIMO_RS16525
• Protein ID: WP_015282265.1
• Coordinates: 3807387..3808139 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: L0H3H2
• Locus tag: THIMO_RS16530
• Protein ID: WP_015282266.1
• Coordinates: 3808197..3808556 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIMO_RS16515	3804012..3805370	-	1359	WP_015282262.1	hypothetical protein	-
THIMO_RS16520	3805406..3807124	-	1719	WP_015282263.1	class I SAM-dependent methyltransferase	-
THIMO_RS16525	3807387..3808139	-	753	WP_015282265.1	RES family NAD+ phosphorylase	Toxin
THIMO_RS16530	3808197..3808556	-	360	WP_015282266.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
THIMO_RS16535	3809128..3810732	+	1605	WP_015282267.1	putative DNA binding domain-containing protein	-
THIMO_RS16540	3810746..3811993	-	1248	WP_041603840.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-211)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (68-117)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 27921.87 Da
• Isoelectric Point: 7.3258

>T28680 WP_015282265.1 NC_019940:c3808139-3807387 [Thioflavicoccus mobilis 8321]
MDLWDRCRERLDIAPLGGELLRMVESQQQVATSELVDDLTEQALLEDLIERSKPPRPAGTGRLHYLLATPFRYPPLRHGS
RFGGRFEASLFYGARRLPTLLAEAAYYRFVFWAAMAAPPPSGRLLTQHSVFAARWQAARGVRLQDPPCADHEPILRDPQD
YRATQRLGSALREVGVGAIEYRSARDAEGGINVALFQPDALVSRTPLRPQAWLCETSAARVRFTCPDGQQLHELPIEGFL
IDGVLPRPAA

Nucleotide

• Length: 753 bp

>T28680 NC_019940:c3808139-3807387 [Thioflavicoccus mobilis 8321]
ATGGATCTCTGGGATCGGTGTCGCGAGCGGCTCGATATCGCCCCGCTCGGCGGCGAGCTGCTGCGGATGGTCGAGAGCCA
GCAGCAGGTCGCGACCTCCGAACTCGTCGACGACCTGACCGAGCAGGCCCTGTTGGAGGACCTGATCGAGCGCTCCAAGC
CGCCCCGGCCCGCCGGCACCGGGCGACTCCACTACCTGCTCGCGACGCCATTTCGTTATCCGCCACTGCGCCACGGCTCG
CGCTTCGGGGGCCGCTTCGAGGCGAGCCTCTTCTACGGTGCCCGCCGCCTGCCGACGCTGCTCGCCGAGGCGGCCTACTA
TCGCTTCGTCTTCTGGGCGGCGATGGCGGCCCCGCCACCGTCCGGTCGGCTCCTGACCCAGCACAGCGTCTTCGCCGCCC
GCTGGCAGGCCGCGCGCGGCGTGCGCCTCCAGGACCCGCCGTGTGCCGACCACGAACCGATCCTGCGCGACCCGCAGGAC
TATCGGGCGACGCAGCGGCTCGGCTCGGCGCTGCGCGAGGTGGGCGTCGGCGCCATCGAATACCGCTCCGCCCGCGACGC
TGAGGGCGGCATCAATGTCGCGCTGTTCCAGCCCGATGCGCTGGTCAGCCGCACCCCGCTGCGACCCCAGGCGTGGCTCT
GCGAGACTAGCGCGGCGCGGGTACGCTTCACCTGCCCGGACGGCCAACAGCTCCACGAGCTGCCGATCGAGGGCTTTCTC
ATCGACGGTGTGCTGCCGCGCCCGGCTGCCTGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 12981.94 Da
• Isoelectric Point: 9.7232

>AT28680 WP_015282266.1 NC_019940:c3808556-3808197 [Thioflavicoccus mobilis 8321]
MSTFAVQTQPDPRAVLSKALLNAGRVLGLSQERIGEVVGRDRTSIARGIDPQSKSGELALLLIRCYRSLYALVGGRPEDM
RHWMQTPNRDTGGIPAEQIGSIPGLIRVVEYLDAMRGHG

Nucleotide

• Length: 360 bp

>AT28680 NC_019940:c3808556-3808197 [Thioflavicoccus mobilis 8321]
ATGTCGACCTTCGCCGTCCAAACCCAGCCCGATCCCCGGGCCGTACTCTCGAAGGCCCTGCTCAATGCCGGGCGGGTGCT
CGGCCTGTCGCAGGAGCGGATCGGCGAGGTCGTCGGGCGTGACCGCACCTCGATCGCCCGCGGGATCGATCCGCAGAGCA
AGTCGGGCGAACTGGCGCTGCTCCTGATCCGCTGTTATCGCAGCCTCTATGCCCTCGTCGGCGGTCGGCCTGAGGACATG
CGCCACTGGATGCAGACGCCGAACCGCGACACGGGCGGTATCCCCGCCGAGCAGATCGGCAGCATTCCGGGGCTGATCCG
GGTCGTCGAGTATCTGGATGCGATGCGCGGCCATGGCTGA

Structures

Toxin

• AlphaFold DB: L0GZF2

Antitoxin

• AlphaFold DB: L0H3H2