Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 182968..183497 Replicon chromosome
Accession NZ_LR134105
Organism Enterococcus faecium isolate E6043

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag ELZ65_RS00945 Protein ID WP_002296560.1
Coordinates 183231..183497 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag ELZ65_RS00940 Protein ID WP_002296559.1
Coordinates 182968..183231 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ65_RS00925 180342..182165 + 1824 WP_002294202.1 APC family permease -
ELZ65_RS00930 182307..182492 - 186 WP_002296558.1 transcriptional regulator -
ELZ65_RS00940 182968..183231 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ65_RS00945 183231..183497 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
ELZ65_RS00950 183698..184186 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
ELZ65_RS00955 184727..185398 - 672 WP_002302663.1 ABC transporter permease -
ELZ65_RS00960 185395..186312 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
ELZ65_RS00965 186309..186950 - 642 WP_002293405.1 ABC transporter permease -
ELZ65_RS00970 186954..187535 - 582 Protein_184 CBS domain-containing protein -
ELZ65_RS00975 187693..188097 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T286798 WP_002296560.1 NZ_LR134105:183231-183497 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT286798 WP_002296559.1 NZ_LR134105:182968-183231 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References