Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 73402..73973 Replicon plasmid 2
Accession NZ_LR134096
Organism Enterococcus faecium isolate E1334

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ59_RS13250 Protein ID WP_002322675.1
Coordinates 73632..73973 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ELZ59_RS13245 Protein ID WP_002322676.1
Coordinates 73402..73632 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ59_RS13220 68474..69028 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
ELZ59_RS13225 69771..70331 + 561 WP_002347210.1 hypothetical protein -
ELZ59_RS13230 70364..71176 - 813 WP_002322679.1 AAA family ATPase -
ELZ59_RS13235 71169..72605 - 1437 WP_002322678.1 DDE-type integrase/transposase/recombinase -
ELZ59_RS13240 72577..73170 - 594 WP_002322677.1 recombinase family protein -
ELZ59_RS13245 73402..73632 + 231 WP_002322676.1 hypothetical protein Antitoxin
ELZ59_RS13250 73632..73973 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ59_RS13255 74187..75689 - 1503 WP_002322674.1 xylulokinase -
ELZ59_RS13260 75762..76814 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
ELZ59_RS13265 76867..77835 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124986 124986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T286797 WP_002322675.1 NZ_LR134096:73632-73973 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT286797 WP_002322676.1 NZ_LR134096:73402-73632 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References