286796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 513121..513692 Replicon chromosome
Accession NZ_LR134095
Organism Enterococcus faecium isolate E1334

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag ELZ59_RS02590 Protein ID WP_002286801.1
Coordinates 513351..513692 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag ELZ59_RS02585 Protein ID WP_002323011.1
Coordinates 513121..513351 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ59_RS02540 508241..509572 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
ELZ59_RS02545 509594..510220 + 627 WP_002286816.1 cysteine hydrolase -
ELZ59_RS02550 510403..510984 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
ELZ59_RS02570 511716..512291 + 576 WP_002293673.1 SOS response-associated peptidase family protein -
ELZ59_RS02575 512496..512834 - 339 WP_126315669.1 hypothetical protein -
ELZ59_RS02585 513121..513351 + 231 WP_002323011.1 hypothetical protein Antitoxin
ELZ59_RS02590 513351..513692 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ59_RS02595 514542..514727 + 186 WP_002304207.1 hypothetical protein -
ELZ59_RS02600 515232..515426 + 195 WP_002295146.1 hypothetical protein -
ELZ59_RS02605 515548..515866 + 319 Protein_486 transposase -
ELZ59_RS02615 516110..516940 - 831 WP_002286789.1 manganese catalase family protein -
ELZ59_RS02620 517148..518481 + 1334 Protein_488 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T286796 WP_002286801.1 NZ_LR134095:513351-513692 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT286796 WP_002323011.1 NZ_LR134095:513121-513351 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References