Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 188559..189088 Replicon chromosome
Accession NZ_LR134095
Organism Enterococcus faecium isolate E1334

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag ELZ59_RS00995 Protein ID WP_002294198.1
Coordinates 188822..189088 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag ELZ59_RS00990 Protein ID WP_002294199.1
Coordinates 188559..188822 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ59_RS00975 185934..187757 + 1824 WP_002294202.1 APC family permease -
ELZ59_RS00980 187899..188084 - 186 WP_002294201.1 hypothetical protein -
ELZ59_RS00990 188559..188822 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ELZ59_RS00995 188822..189088 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
ELZ59_RS01000 189289..189777 + 489 WP_126315637.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
ELZ59_RS13730 189840..190007 + 168 WP_002294195.1 hypothetical protein -
ELZ59_RS01005 190319..190990 - 672 WP_002319469.1 ABC transporter permease -
ELZ59_RS01010 190987..191904 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
ELZ59_RS01015 191901..192542 - 642 WP_002293405.1 ABC transporter permease -
ELZ59_RS01020 192546..193721 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T286795 WP_002294198.1 NZ_LR134095:188822-189088 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT286795 WP_002294199.1 NZ_LR134095:188559-188822 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References