Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2180029..2180543 Replicon chromosome
Accession NZ_LR134093
Organism Staphylococcus aureus strain NCTC11965

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag ELZ56_RS11130 Protein ID WP_000581791.1
Coordinates 2180029..2180238 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag ELZ56_RS11135 Protein ID WP_000138934.1
Coordinates 2180250..2180543 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ56_RS11110 2175918..2176988 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
ELZ56_RS11115 2177306..2178508 + 1203 WP_001109939.1 rod shape-determining protein RodA -
ELZ56_RS11120 2178669..2179352 - 684 Protein_2063 transposase -
ELZ56_RS11125 2179764..2179901 - 138 WP_000828354.1 hypothetical protein -
ELZ56_RS11130 2180029..2180238 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
ELZ56_RS11135 2180250..2180543 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
ELZ56_RS11140 2180709..2182193 + 1485 WP_000571560.1 cardiolipin synthase -
ELZ56_RS11145 2182221..2182868 + 648 WP_001187612.1 HD domain-containing protein -
ELZ56_RS11160 2183481..2184353 - 873 WP_000725802.1 membrane protein insertase YidC -
ELZ56_RS11165 2184439..2185080 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T286790 WP_000581791.1 NZ_LR134093:c2180238-2180029 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT286790 WP_000138934.1 NZ_LR134093:c2180543-2180250 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References