Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3781773..3782536 Replicon chromosome
Accession NC_019940
Organism Thioflavicoccus mobilis 8321

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag THIMO_RS16415 Protein ID WP_041604670.1
Coordinates 3782042..3782536 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L0H3F0
Locus tag THIMO_RS16410 Protein ID WP_015282241.1
Coordinates 3781773..3782045 (+) Length 91 a.a.

Genomic Context

THIMO_RS18530THIMO_RS16395THIMO_RS16400THIMO_RS16405THIMO_RS16410THIMO_RS16415THIMO_RS16420THIMO_RS16425THIMO_RS20150THIMO_RS16435THIMO_RS16440THIMO_RS16385
Location: 3778668..3779405 (738 bp)
Type: Others
Protein ID: WP_015282237.1
Location: 3780019..3780420 (402 bp)
Type: Others
Protein ID: WP_015282238.1
Location: 3780401..3781096 (696 bp)
Type: Others
Protein ID: WP_015282239.1
Location: 3781130..3781348 (219 bp)
Type: Others
Protein ID: WP_015282240.1
Location: 3781773..3782045 (273 bp)
Type: Antitoxin
Protein ID: WP_015282241.1
Location: 3782042..3782536 (495 bp)
Type: Toxin
Protein ID: WP_041604670.1
Location: 3782840..3785017 (2178 bp)
Type: Others
Protein ID: WP_015282243.1
Location: 3785014..3786357 (1344 bp)
Type: Others
Protein ID: WP_015282244.1
Location: 3786583..3786720 (138 bp)
Type: Others
Protein ID: WP_157633795.1
Location: 3786807..3787088 (282 bp)
Type: Others
Protein ID: WP_015282245.1
Location: 3787101..3787460 (360 bp)
Type: Others
Protein ID: WP_015282246.1
Location: 3777704..3778531 (828 bp)
Type: Others
Protein ID: WP_015282236.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
THIMO_RS163853777704..3778531-828WP_015282236.1Hsp20/alpha crystallin family protein-
THIMO_RS185303778668..3779405+738WP_015282237.1nucleoside phosphorylase-
THIMO_RS163953780019..3780420+402WP_015282238.1MbcA/ParS/Xre antitoxin family protein-
THIMO_RS164003780401..3781096+696WP_015282239.1RES family NAD+ phosphorylase-
THIMO_RS164053781130..3781348+219WP_015282240.1hypothetical protein-
THIMO_RS164103781773..3782045+273WP_015282241.1DUF1778 domain-containing proteinAntitoxin
THIMO_RS164153782042..3782536+495WP_041604670.1GNAT family N-acetyltransferaseToxin
THIMO_RS164203782840..3785017+2178WP_015282243.1type I restriction-modification system subunit M-
THIMO_RS164253785014..3786357+1344WP_015282244.1restriction endonuclease subunit S-
THIMO_RS201503786583..3786720+138WP_157633795.1hypothetical protein-
THIMO_RS164353786807..3787088+282WP_015282245.1type II toxin-antitoxin system RelE/ParE family toxin-
THIMO_RS164403787101..3787460+360WP_015282246.1HigA family addiction module antidote protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-148)

Antitoxin

Vibrio phage ICP1, Orf50

(3-87)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17733.31 Da        Isoelectric Point: 8.9724

>T28679 WP_041604670.1 NC_019940:3782042-3782536 [Thioflavicoccus mobilis 8321]
ISRLLSAPHPLAAAHVLDEFACGEASLDEWLKRRALTNQLSGASRTFVVSDQDGRVQGYYAMAAGAVSHQAATSAVRRNM
PDPVPVMVLARLSIDHRAQGIKLGGALLQDAVHRAVAVSQNAGVRALLVHALHDHAKAFYEHYGFQASPLHPMTLMLRLH
AHEP

Download         Length: 495 bp

>T28679 NC_019940:3782042-3782536 [Thioflavicoccus mobilis 8321]
ATAAGCAGGCTCTTGAGCGCGCCGCACCCCCTCGCGGCCGCCCACGTCCTGGACGAGTTCGCCTGCGGGGAGGCCAGCCT
CGATGAATGGCTCAAACGCCGGGCATTGACGAACCAGTTGAGCGGCGCAAGCCGCACCTTCGTCGTCAGCGATCAGGACG
GGCGTGTCCAGGGCTACTACGCGATGGCCGCAGGTGCGGTTTCACACCAAGCCGCCACCAGTGCCGTGCGCCGCAACATG
CCTGACCCGGTGCCCGTGATGGTGCTCGCGAGGCTATCCATCGATCATCGCGCCCAAGGCATCAAGCTGGGCGGGGCCTT
GCTGCAGGACGCGGTTCATCGGGCTGTGGCGGTCTCGCAAAACGCCGGGGTTCGGGCGCTGCTGGTGCACGCGCTCCACG
ACCACGCCAAGGCGTTCTACGAGCATTACGGTTTTCAGGCGTCGCCGCTCCATCCGATGACGCTGATGTTGCGGCTCCAT
GCGCACGAGCCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9873.29 Da        Isoelectric Point: 5.0175

>AT28679 WP_015282241.1 NC_019940:3781773-3782045 [Thioflavicoccus mobilis 8321]
MRDAAINLRALPEQRDLIDHAASLLGKSRSEFMLEAACDRARSVVLDQVFFSLDADKFQQFTAMLDAPPSPNPGLERLMA
VKAPWNTGGA

Download         Length: 273 bp

>AT28679 NC_019940:3781773-3782045 [Thioflavicoccus mobilis 8321]
ATGCGTGATGCCGCCATCAATCTACGGGCGCTGCCTGAGCAGCGTGATCTGATCGATCACGCGGCCAGCCTGCTCGGTAA
AAGCCGGTCTGAATTCATGCTCGAAGCGGCCTGCGACCGAGCACGGTCCGTGGTGCTGGATCAGGTCTTTTTCAGCCTGG
ACGCAGACAAGTTCCAGCAATTCACCGCGATGCTCGATGCGCCTCCGAGCCCCAACCCCGGGCTTGAACGCCTGATGGCC
GTCAAAGCACCGTGGAACACCGGCGGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBL0H3F0

References