Detailed information of TA system TA028679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3781773..3782536
• Replicon: chromosome
• Accession: NC_019940
• Organism: Thioflavicoccus mobilis 8321

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: THIMO_RS16415
• Protein ID: WP_041604670.1
• Coordinates: 3782042..3782536 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: L0H3F0
• Locus tag: THIMO_RS16410
• Protein ID: WP_015282241.1
• Coordinates: 3781773..3782045 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIMO_RS16385	3777704..3778531	-	828	WP_015282236.1	Hsp20/alpha crystallin family protein	-
THIMO_RS18530	3778668..3779405	+	738	WP_015282237.1	nucleoside phosphorylase	-
THIMO_RS16395	3780019..3780420	+	402	WP_015282238.1	MbcA/ParS/Xre antitoxin family protein	-
THIMO_RS16400	3780401..3781096	+	696	WP_015282239.1	RES family NAD+ phosphorylase	-
THIMO_RS16405	3781130..3781348	+	219	WP_015282240.1	hypothetical protein	-
THIMO_RS16410	3781773..3782045	+	273	WP_015282241.1	DUF1778 domain-containing protein	Antitoxin
THIMO_RS16415	3782042..3782536	+	495	WP_041604670.1	GNAT family N-acetyltransferase	Toxin
THIMO_RS16420	3782840..3785017	+	2178	WP_015282243.1	type I restriction-modification system subunit M	-
THIMO_RS16425	3785014..3786357	+	1344	WP_015282244.1	restriction endonuclease subunit S	-
THIMO_RS20150	3786583..3786720	+	138	WP_157633795.1	hypothetical protein	-
THIMO_RS16435	3786807..3787088	+	282	WP_015282245.1	type II toxin-antitoxin system RelE/ParE family toxin	-
THIMO_RS16440	3787101..3787460	+	360	WP_015282246.1	HigA family addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-87)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17733.31 Da
• Isoelectric Point: 8.9724

>T28679 WP_041604670.1 NC_019940:3782042-3782536 [Thioflavicoccus mobilis 8321]
ISRLLSAPHPLAAAHVLDEFACGEASLDEWLKRRALTNQLSGASRTFVVSDQDGRVQGYYAMAAGAVSHQAATSAVRRNM
PDPVPVMVLARLSIDHRAQGIKLGGALLQDAVHRAVAVSQNAGVRALLVHALHDHAKAFYEHYGFQASPLHPMTLMLRLH
AHEP

Nucleotide

• Length: 495 bp

>T28679 NC_019940:3782042-3782536 [Thioflavicoccus mobilis 8321]
ATAAGCAGGCTCTTGAGCGCGCCGCACCCCCTCGCGGCCGCCCACGTCCTGGACGAGTTCGCCTGCGGGGAGGCCAGCCT
CGATGAATGGCTCAAACGCCGGGCATTGACGAACCAGTTGAGCGGCGCAAGCCGCACCTTCGTCGTCAGCGATCAGGACG
GGCGTGTCCAGGGCTACTACGCGATGGCCGCAGGTGCGGTTTCACACCAAGCCGCCACCAGTGCCGTGCGCCGCAACATG
CCTGACCCGGTGCCCGTGATGGTGCTCGCGAGGCTATCCATCGATCATCGCGCCCAAGGCATCAAGCTGGGCGGGGCCTT
GCTGCAGGACGCGGTTCATCGGGCTGTGGCGGTCTCGCAAAACGCCGGGGTTCGGGCGCTGCTGGTGCACGCGCTCCACG
ACCACGCCAAGGCGTTCTACGAGCATTACGGTTTTCAGGCGTCGCCGCTCCATCCGATGACGCTGATGTTGCGGCTCCAT
GCGCACGAGCCATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9873.29 Da
• Isoelectric Point: 5.0175

>AT28679 WP_015282241.1 NC_019940:3781773-3782045 [Thioflavicoccus mobilis 8321]
MRDAAINLRALPEQRDLIDHAASLLGKSRSEFMLEAACDRARSVVLDQVFFSLDADKFQQFTAMLDAPPSPNPGLERLMA
VKAPWNTGGA

Nucleotide

• Length: 273 bp

>AT28679 NC_019940:3781773-3782045 [Thioflavicoccus mobilis 8321]
ATGCGTGATGCCGCCATCAATCTACGGGCGCTGCCTGAGCAGCGTGATCTGATCGATCACGCGGCCAGCCTGCTCGGTAA
AAGCCGGTCTGAATTCATGCTCGAAGCGGCCTGCGACCGAGCACGGTCCGTGGTGCTGGATCAGGTCTTTTTCAGCCTGG
ACGCAGACAAGTTCCAGCAATTCACCGCGATGCTCGATGCGCCTCCGAGCCCCAACCCCGGGCTTGAACGCCTGATGGCC
GTCAAAGCACCGTGGAACACCGGCGGGGCATAA

Structures

Antitoxin

• AlphaFold DB: L0H3F0