Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4699129..4699724 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag EL041_RS22665 Protein ID WP_000239577.1
Coordinates 4699129..4699479 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EL041_RS22670 Protein ID WP_001223208.1
Coordinates 4699473..4699724 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS22645 4694578..4695600 - 1023 WP_126298077.1 ABC transporter permease -
EL041_RS22650 4695614..4697116 - 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
EL041_RS22655 4697256..4698212 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EL041_RS22660 4698522..4699052 + 531 WP_000055075.1 inorganic diphosphatase -
EL041_RS22665 4699129..4699479 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
EL041_RS22670 4699473..4699724 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EL041_RS22675 4699936..4700277 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EL041_RS22680 4700280..4704059 - 3780 WP_000060966.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T286778 WP_000239577.1 NZ_LR134092:c4699479-4699129 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT286778 WP_001223208.1 NZ_LR134092:c4699724-4699473 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References