Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4573958..4574756 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag EL041_RS22060 Protein ID WP_000854919.1
Coordinates 4573958..4574335 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL041_RS22065 Protein ID WP_047088564.1
Coordinates 4574382..4574756 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS22030 4569458..4569637 + 180 WP_001153034.1 hypothetical protein -
EL041_RS22035 4570036..4572072 - 2037 WP_089507572.1 hypothetical protein -
EL041_RS25610 4573025..4573171 - 147 WP_001290177.1 hypothetical protein -
EL041_RS22050 4573256..4573453 - 198 WP_001327226.1 DUF957 domain-containing protein -
EL041_RS22055 4573473..4573961 - 489 WP_000777664.1 hypothetical protein -
EL041_RS22060 4573958..4574335 - 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
EL041_RS22065 4574382..4574756 - 375 WP_047088564.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL041_RS22070 4574836..4575057 - 222 WP_000692350.1 DUF987 domain-containing protein -
EL041_RS22075 4575144..4575620 - 477 WP_001186188.1 RadC family protein -
EL041_RS22080 4575635..4576114 - 480 WP_000706980.1 antirestriction protein -
EL041_RS22085 4576380..4577198 - 819 WP_001175165.1 DUF945 domain-containing protein -
EL041_RS22090 4577288..4577521 - 234 WP_001278293.1 DUF905 family protein -
EL041_RS22095 4577527..4578204 - 678 WP_001097302.1 hypothetical protein -
EL041_RS22100 4578352..4579032 - 681 WP_001282922.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4564528..4594868 30340
- inside Genomic island - - 4564528..4582038 17510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T286777 WP_000854919.1 NZ_LR134092:c4574335-4573958 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13600.33 Da        Isoelectric Point: 5.5051

>AT286777 WP_047088564.1 NZ_LR134092:c4574756-4574382 [Escherichia coli]
VSDTLSGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure

References