Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4484126..4484702 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name shpA Uniprot ID A0A061KXE4
Locus tag EL041_RS21745 Protein ID WP_001295743.1
Coordinates 4484415..4484702 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A066STF6
Locus tag EL041_RS21740 Protein ID WP_000063148.1
Coordinates 4484126..4484428 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS21720 4479887..4480429 + 543 WP_000934391.1 hypothetical protein -
EL041_RS21725 4480722..4482872 + 2151 WP_001298933.1 pyruvate/proton symporter BtsT -
EL041_RS21730 4482922..4483125 + 204 WP_000467859.1 YbdD/YjiX family protein -
EL041_RS21735 4483136..4484092 + 957 WP_089625875.1 GTPase -
EL041_RS21740 4484126..4484428 - 303 WP_000063148.1 BrnA antitoxin family protein Antitoxin
EL041_RS21745 4484415..4484702 - 288 WP_001295743.1 BrnT family toxin Toxin
EL041_RS21750 4484899..4486065 + 1167 WP_000800831.1 restriction endonuclease -
EL041_RS21755 4486129..4487748 + 1620 WP_089625877.1 type I restriction-modification system subunit M -
EL041_RS21760 4487738..4489051 + 1314 WP_097177238.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11156.62 Da        Isoelectric Point: 7.4697

>T286776 WP_001295743.1 NZ_LR134092:c4484702-4484415 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11592.12 Da        Isoelectric Point: 9.4646

>AT286776 WP_000063148.1 NZ_LR134092:c4484428-4484126 [Escherichia coli]
MSMVKHKRGTPSTLDVQHEAELKALANKFDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KXE4

Antitoxin

Source ID Structure
AlphaFold DB A0A066STF6

References