Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3911439..3912057 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL041_RS19085 Protein ID WP_001291435.1
Coordinates 3911839..3912057 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL041_RS19080 Protein ID WP_000344800.1
Coordinates 3911439..3911813 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS19070 3906528..3907721 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL041_RS19075 3907744..3910893 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL041_RS19080 3911439..3911813 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL041_RS19085 3911839..3912057 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL041_RS19090 3912229..3912780 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL041_RS19095 3912896..3913366 + 471 WP_000136192.1 YlaC family protein -
EL041_RS19100 3913530..3915080 + 1551 WP_001362407.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL041_RS19105 3915122..3915475 - 354 WP_000878146.1 DUF1428 family protein -
EL041_RS19115 3915854..3916165 + 312 WP_000409914.1 MGMT family protein -
EL041_RS19120 3916196..3916768 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286773 WP_001291435.1 NZ_LR134092:3911839-3912057 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286773 WP_000344800.1 NZ_LR134092:3911439-3911813 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References