Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3313750..3314568 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag EL041_RS16190 Protein ID WP_000771609.1
Coordinates 3313750..3314124 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag EL041_RS16195 Protein ID WP_001285568.1
Coordinates 3314215..3314568 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS16160 3310428..3311132 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
EL041_RS16165 3311417..3311635 + 219 WP_001040187.1 translation initiation factor IF-1 -
EL041_RS16175 3312126..3312968 - 843 WP_001274560.1 DUF4942 domain-containing protein -
EL041_RS16180 3313053..3313250 - 198 WP_000839270.1 DUF957 domain-containing protein -
EL041_RS16185 3313262..3313753 - 492 WP_000976860.1 hypothetical protein -
EL041_RS16190 3313750..3314124 - 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
EL041_RS16195 3314215..3314568 - 354 WP_001285568.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EL041_RS16200 3314644..3314865 - 222 WP_000692357.1 DUF987 domain-containing protein -
EL041_RS16205 3314928..3315404 - 477 WP_001186756.1 RadC family protein -
EL041_RS16210 3315420..3315893 - 474 WP_000855049.1 antirestriction protein -
EL041_RS16215 3315987..3316232 - 246 WP_001164966.1 hypothetical protein -
EL041_RS16220 3316232..3317053 - 822 WP_001241709.1 DUF945 domain-containing protein -
EL041_RS16230 3317274..3317684 - 411 WP_000846716.1 hypothetical protein -
EL041_RS16235 3317700..3318383 - 684 WP_000775510.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T286772 WP_000771609.1 NZ_LR134092:c3314124-3313750 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT286772 WP_001285568.1 NZ_LR134092:c3314568-3314215 [Escherichia coli]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References