Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2656820..2657458 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name hicA Uniprot ID A0A080J2T0
Locus tag EL041_RS12875 Protein ID WP_000813793.1
Coordinates 2657282..2657458 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL041_RS12870 Protein ID WP_001270286.1
Coordinates 2656820..2657236 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS12850 2651972..2652913 - 942 WP_001251315.1 ABC transporter permease -
EL041_RS12855 2652914..2653927 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
EL041_RS12860 2653945..2655090 - 1146 WP_000047419.1 ABC transporter substrate-binding protein -
EL041_RS12865 2655335..2656741 - 1407 WP_000760655.1 PLP-dependent aminotransferase family protein -
EL041_RS12870 2656820..2657236 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL041_RS12875 2657282..2657458 - 177 WP_000813793.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL041_RS12880 2657680..2657910 + 231 WP_000494244.1 YncJ family protein -
EL041_RS12885 2658002..2659963 - 1962 WP_024257894.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL041_RS12890 2660036..2660572 - 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
EL041_RS12895 2660625..2661836 + 1212 WP_023154256.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.83 Da        Isoelectric Point: 10.9223

>T286770 WP_000813793.1 NZ_LR134092:c2657458-2657282 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGMRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT286770 WP_001270286.1 NZ_LR134092:c2657236-2656820 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A080J2T0

Antitoxin

Source ID Structure

References