Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3015591..3016171 Replicon chromosome
Accession NC_019940
Organism Thioflavicoccus mobilis 8321

Toxin (Protein)


Gene name vapC Uniprot ID L0GZP0
Locus tag THIMO_RS13005 Protein ID WP_015281568.1
Coordinates 3015591..3015962 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L0H044
Locus tag THIMO_RS13010 Protein ID WP_015281569.1
Coordinates 3015950..3016171 (-) Length 74 a.a.

Genomic Context

THIMO_RS12990THIMO_RS12995THIMO_RS13000THIMO_RS13005THIMO_RS13010THIMO_RS13015THIMO_RS20270THIMO_RS19235
Location: 3013455..3013877 (423 bp)
Type: Others
Protein ID: WP_015281564.1
Location: 3013861..3014103 (243 bp)
Type: Others
Protein ID: WP_015281565.1
Location: 3014681..3014983 (303 bp)
Type: Others
Protein ID: WP_015281567.1
Location: 3015591..3015962 (372 bp)
Type: Toxin
Protein ID: WP_015281568.1
Location: 3015950..3016171 (222 bp)
Type: Antitoxin
Protein ID: WP_015281569.1
Location: 3017183..3018127 (945 bp)
Type: Others
Protein ID: WP_015281571.1
Location: 3019024..3019377 (354 bp)
Type: Others
Protein ID: WP_015281572.1
Location: 3019374..3019626 (253 bp)
Type: Others
Protein ID: Protein_2657
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
THIMO_RS129903013455..3013877-423WP_015281564.1putative toxin-antitoxin system toxin component, PIN family-
THIMO_RS129953013861..3014103-243WP_015281565.1hypothetical protein-
THIMO_RS130003014681..3014983-303WP_015281567.1nucleotidyltransferase family protein-
THIMO_RS130053015591..3015962-372WP_015281568.1type II toxin-antitoxin system VapC family toxinToxin
THIMO_RS130103015950..3016171-222WP_015281569.1ribbon-helix-helix domain-containing proteinAntitoxin
THIMO_RS130153017183..3018127-945WP_015281571.1ferritin family protein-
THIMO_RS202703019024..3019377-354WP_015281572.1DUF5615 family PIN-like protein-
THIMO_RS192353019374..3019626-253Protein_2657DUF433 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--3004749..301962614877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13872.18 Da        Isoelectric Point: 8.9882

>T28677 WP_015281568.1 NC_019940:c3015962-3015591 [Thioflavicoccus mobilis 8321]
MGPVKALFDTNILIDYLNGVVAARDEIGRYQRPLISLINWMEVLTGTPAEHAQPVRAFLRRFECVGIDAEIAERAVNLRQ
AQRLKLPDAIIRATAMERSALLVTRNTKDFLADEPGIRIPYKL

Download         Length: 372 bp

>T28677 NC_019940:c3015962-3015591 [Thioflavicoccus mobilis 8321]
ATGGGACCGGTGAAGGCGCTGTTCGACACCAACATCCTGATCGACTACCTGAACGGTGTGGTCGCGGCCCGCGACGAGAT
CGGCCGCTACCAGAGGCCCCTGATCAGTCTGATCAATTGGATGGAGGTCTTGACGGGTACGCCAGCGGAGCACGCCCAGC
CGGTCCGTGCCTTCTTGCGCCGCTTCGAGTGCGTCGGCATCGACGCAGAAATCGCCGAGCGTGCGGTCAATCTCAGGCAG
GCGCAGCGCCTCAAGCTTCCTGATGCGATCATCCGTGCCACCGCAATGGAGCGCAGTGCCCTGCTGGTGACACGCAATAC
CAAGGATTTCCTTGCGGACGAGCCTGGCATCCGTATCCCCTATAAGTTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8476.41 Da        Isoelectric Point: 4.6413

>AT28677 WP_015281569.1 NC_019940:c3016171-3015950 [Thioflavicoccus mobilis 8321]
MRTVIDLPDDQIAPLKDLAESLNVSRAELIRRAVTDFLRRHEVPTEDAAFGIWRGHDEDGVAYQERARSEWDR

Download         Length: 222 bp

>AT28677 NC_019940:c3016171-3015950 [Thioflavicoccus mobilis 8321]
ATGCGCACAGTTATCGACCTGCCGGACGACCAAATCGCGCCGCTCAAGGATCTGGCGGAGTCCCTCAATGTCTCGCGCGC
CGAGCTGATTCGGCGTGCGGTGACTGACTTCCTGCGCCGGCACGAGGTGCCGACGGAAGATGCAGCGTTCGGCATCTGGA
GGGGGCATGATGAAGACGGTGTCGCCTACCAAGAGCGCGCGCGCTCGGAATGGGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBL0GZP0

Antitoxin

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Source
ID
Structure
AlphaFold DBL0H044

References