Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2488772..2489298 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL041_RS12110 Protein ID WP_000323025.1
Coordinates 2489011..2489298 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL041_RS12105 Protein ID WP_000534858.1
Coordinates 2488772..2489011 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS12070 2483958..2484185 + 228 WP_000476993.1 transcriptional regulator -
EL041_RS12075 2484169..2484690 + 522 WP_000705349.1 hypothetical protein -
EL041_RS12080 2484671..2485636 + 966 WP_000054506.1 hypothetical protein -
EL041_RS12085 2485677..2486096 + 420 WP_001151195.1 DUF977 family protein -
EL041_RS12090 2486130..2487470 + 1341 WP_126297860.1 ISNCY family transposase -
EL041_RS12095 2487907..2488239 - 333 WP_001301033.1 protein FlxA -
EL041_RS12100 2488442..2488747 - 306 WP_001326990.1 hypothetical protein -
EL041_RS12105 2488772..2489011 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL041_RS12110 2489011..2489298 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL041_RS12115 2489370..2489525 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL041_RS12120 2489742..2489993 + 252 WP_000981000.1 hypothetical protein -
EL041_RS12125 2490060..2490338 + 279 WP_032140164.1 hypothetical protein -
EL041_RS12130 2490340..2491389 + 1050 WP_001265195.1 DUF968 domain-containing protein -
EL041_RS12135 2491403..2492155 + 753 WP_001047135.1 antitermination protein -
EL041_RS12140 2492433..2492522 - 90 WP_120795389.1 hypothetical protein -
EL041_RS12145 2492577..2492789 - 213 WP_000087757.1 cold shock-like protein CspF -
EL041_RS12150 2493090..2493305 + 216 WP_000066484.1 cold shock-like protein CspB -
EL041_RS25815 2493669..2493839 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
EL041_RS12155 2494059..2494274 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2477351..2533769 56418
- inside Prophage - - 2467211..2536432 69221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286768 WP_000323025.1 NZ_LR134092:2489011-2489298 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286768 WP_000534858.1 NZ_LR134092:2488772-2489011 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References