Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1433452..1434077 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag EL041_RS06960 Protein ID WP_000911329.1
Coordinates 1433679..1434077 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL041_RS06955 Protein ID WP_000450524.1
Coordinates 1433452..1433679 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS06930 1429254..1429724 - 471 WP_001068690.1 thioredoxin-dependent thiol peroxidase -
EL041_RS06935 1429724..1430296 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL041_RS06940 1430442..1431320 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL041_RS06945 1431337..1432371 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL041_RS06950 1432584..1433297 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL041_RS06955 1433452..1433679 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL041_RS06960 1433679..1434077 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL041_RS06965 1434224..1435087 + 864 WP_001267498.1 neutral zinc metallopeptidase -
EL041_RS06970 1435102..1437117 + 2016 WP_000829353.1 tRNA cytosine(34) acetyltransferase TmcA -
EL041_RS06975 1437191..1437889 + 699 WP_000679812.1 esterase -
EL041_RS06980 1437970..1438170 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T286762 WP_000911329.1 NZ_LR134092:1433679-1434077 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT286762 WP_000450524.1 NZ_LR134092:1433452-1433679 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References