Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 310993..311624 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag EL041_RS01425 Protein ID WP_001259385.1
Coordinates 310993..311268 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag EL041_RS01430 Protein ID WP_000593555.1
Coordinates 311265..311624 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS01410 305997..307064 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
EL041_RS01415 307061..309796 + 2736 WP_000149185.1 ribosome-associated ATPase/putative transporter RbbA -
EL041_RS01420 309796..310920 + 1125 WP_001314210.1 ABC transporter permease -
EL041_RS01425 310993..311268 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
EL041_RS01430 311265..311624 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL041_RS01435 311674..312534 - 861 WP_001131795.1 class II aldolase -
EL041_RS01440 312566..312835 - 270 WP_000933060.1 HPr family phosphocarrier protein -
EL041_RS01445 312825..314333 - 1509 WP_001298718.1 carbohydrate kinase -
EL041_RS01450 314326..315684 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
EL041_RS01455 315761..316042 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
EL041_RS01460 316039..316512 - 474 WP_001161550.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T286756 WP_001259385.1 NZ_LR134092:310993-311268 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT286756 WP_000593555.1 NZ_LR134092:311265-311624 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References