Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 50817..51649 Replicon chromosome
Accession NZ_LR134092
Organism Escherichia coli strain NCTC10444

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag EL041_RS00255 Protein ID WP_000854753.1
Coordinates 50817..51191 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag EL041_RS00260 Protein ID WP_001280951.1
Coordinates 51281..51649 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL041_RS00225 46183..47106 - 924 WP_000535963.1 carboxylate/amino acid/amine transporter -
EL041_RS00230 47217..48401 - 1185 WP_001172876.1 sugar efflux transporter -
EL041_RS00240 49193..50038 - 846 WP_001406222.1 DUF4942 domain-containing protein -
EL041_RS00245 50123..50320 - 198 WP_000839243.1 DUF957 domain-containing protein -
EL041_RS00250 50332..50820 - 489 WP_001549830.1 hypothetical protein -
EL041_RS00255 50817..51191 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
EL041_RS00260 51281..51649 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL041_RS00265 51812..52033 - 222 WP_001405861.1 DUF987 domain-containing protein -
EL041_RS00270 52102..52578 - 477 WP_001186724.1 RadC family protein -
EL041_RS00275 52594..53079 - 486 WP_001469549.1 antirestriction protein -
EL041_RS00280 53134..53952 - 819 WP_001234620.1 DUF945 domain-containing protein -
EL041_RS00290 54052..54285 - 234 WP_001119729.1 DUF905 family protein -
EL041_RS00295 54364..54819 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T286755 WP_000854753.1 NZ_LR134092:c51191-50817 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT286755 WP_001280951.1 NZ_LR134092:c51649-51281 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References