Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2099287..2099801 Replicon chromosome
Accession NZ_LR134091
Organism Staphylococcus aureus strain NCTC4137

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ELZ58_RS10835 Protein ID WP_000581792.1
Coordinates 2099287..2099496 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ELZ58_RS10840 Protein ID WP_000138932.1
Coordinates 2099508..2099801 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ58_RS10815 2094795..2096153 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ELZ58_RS10820 2096168..2097238 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ELZ58_RS10825 2097556..2098758 + 1203 WP_001109939.1 rod shape-determining protein RodA -
ELZ58_RS10830 2099022..2099159 - 138 WP_000828354.1 hypothetical protein -
ELZ58_RS10835 2099287..2099496 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ELZ58_RS10840 2099508..2099801 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ELZ58_RS10845 2099967..2101451 + 1485 WP_000571549.1 cardiolipin synthase -
ELZ58_RS10850 2101479..2102126 + 648 WP_001187630.1 HD domain-containing protein -
ELZ58_RS10865 2102731..2103603 - 873 WP_000725802.1 membrane protein insertase YidC -
ELZ58_RS10870 2103689..2104330 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T286751 WP_000581792.1 NZ_LR134091:c2099496-2099287 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT286751 WP_000138932.1 NZ_LR134091:c2099801-2099508 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References