Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2079533..2080062 Replicon chromosome
Accession NZ_LR134091
Organism Staphylococcus aureus strain NCTC4137

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ58_RS10745 Protein ID WP_000621175.1
Coordinates 2079533..2079895 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ58_RS10750 Protein ID WP_000948331.1
Coordinates 2079892..2080062 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ58_RS10720 2076511..2077281 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
ELZ58_RS10725 2077256..2077735 - 480 WP_001190829.1 anti-sigma B factor RsbW -
ELZ58_RS10730 2077737..2078063 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ58_RS10735 2078182..2079183 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ58_RS10745 2079533..2079895 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ58_RS10750 2079892..2080062 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ58_RS10755 2080147..2081295 - 1149 WP_001281154.1 alanine racemase -
ELZ58_RS10760 2081361..2081720 - 360 WP_000581197.1 holo-ACP synthase -
ELZ58_RS10765 2081724..2082215 - 492 WP_001205912.1 PH domain-containing protein -
ELZ58_RS10770 2082202..2083785 - 1584 WP_126508764.1 PH domain-containing protein -
ELZ58_RS10775 2083778..2084257 - 480 WP_001287079.1 hypothetical protein -
ELZ58_RS10780 2084466..2085026 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286750 WP_000621175.1 NZ_LR134091:c2079895-2079533 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286750 WP_000948331.1 NZ_LR134091:c2080062-2079892 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References