Detailed information of TA system TA028674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 440347..440999
• Replicon: chromosome
• Accession: NC_019940
• Organism: Thioflavicoccus mobilis 8321

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THIMO_RS01920
• Protein ID: WP_015279416.1
• Coordinates: 440601..440999 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0GTX7
• Locus tag: THIMO_RS01915
• Protein ID: WP_015279415.1
• Coordinates: 440347..440601 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIMO_RS01900	435984..437060	-	1077	WP_015279412.1	alkene reductase	-
THIMO_RS01905	437145..438032	-	888	WP_015279413.1	thioredoxin	-
THIMO_RS01910	438187..439128	+	942	WP_015279414.1	LysR family transcriptional regulator	-
THIMO_RS19640	439752..440009	+	258	Protein_402	helix-turn-helix domain-containing protein	-
THIMO_RS01915	440347..440601	+	255	WP_015279415.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
THIMO_RS01920	440601..440999	+	399	WP_015279416.1	type II toxin-antitoxin system VapC family toxin	Toxin
THIMO_RS01925	441285..441491	+	207	WP_015279417.1	hypothetical protein	-
THIMO_RS01930	441514..442113	-	600	WP_015279418.1	GNAT family N-acetyltransferase	-
THIMO_RS01935	442110..443102	-	993	WP_015279419.1	flippase-like domain-containing protein	-
THIMO_RS01940	443099..444016	-	918	WP_015279420.1	Lauroyl/myristoyl acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (2-83)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14327.46 Da
• Isoelectric Point: 4.9285

>T28674 WP_015279416.1 NC_019940:440601-440999 [Thioflavicoccus mobilis 8321]
MVIDTSALVAILQDEPERRRFNEAIEAAPLCHISAATLVEISIVVEARHGAEGIRDLDLFIAAAGIQPVPVDAEQALAAR
EAFRRYGKGRHAAGLNLGDCFSYALARVRDEPLLFKGLDFPQTDVLIAVPLH

Nucleotide

• Length: 399 bp

>T28674 NC_019940:440601-440999 [Thioflavicoccus mobilis 8321]
ATGGTGATCGACACCTCGGCGCTCGTCGCGATTTTGCAGGACGAACCGGAGCGGCGGCGCTTCAACGAGGCCATCGAGGC
CGCGCCGCTCTGTCATATCTCCGCGGCGACGCTGGTGGAGATATCGATTGTCGTCGAGGCGCGCCATGGCGCGGAAGGGA
TCCGCGACCTGGATCTCTTCATTGCCGCGGCGGGCATCCAGCCCGTGCCGGTGGACGCCGAGCAGGCCCTGGCGGCGCGC
GAGGCATTCCGCCGCTACGGCAAGGGACGTCACGCGGCGGGCCTAAACCTCGGTGACTGCTTCTCTTACGCACTGGCGCG
GGTGCGCGACGAACCGCTATTGTTCAAAGGGTTGGACTTTCCGCAGACCGACGTCCTAATCGCAGTGCCTTTGCACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9522.75 Da
• Isoelectric Point: 6.9845

>AT28674 WP_015279415.1 NC_019940:440347-440601 [Thioflavicoccus mobilis 8321]
VALNIRNPETERLAERISELTGETKTAAVTRALRERLERLQREHSGQSLADRLDAIACRMARLPVRDARTPEEILGYDDN
GLPR

Nucleotide

• Length: 255 bp

>AT28674 NC_019940:440347-440601 [Thioflavicoccus mobilis 8321]
GTGGCACTCAACATTCGCAATCCGGAGACCGAAAGGCTTGCCGAGCGCATCTCCGAACTGACGGGGGAGACCAAGACGGC
CGCCGTTACCAGGGCATTGCGCGAGCGGCTGGAACGATTGCAGCGGGAGCACTCCGGCCAGAGCCTGGCGGACCGGCTCG
ATGCCATCGCCTGCCGTATGGCAAGGCTGCCGGTGCGCGATGCCCGCACGCCGGAAGAGATCCTCGGCTACGACGATAAC
GGTCTGCCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: L0GTX7