Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2168124..2168653 Replicon chromosome
Accession NZ_LR134090
Organism Staphylococcus aureus strain NCTC9555

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ60_RS11360 Protein ID WP_000621175.1
Coordinates 2168124..2168486 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ60_RS11365 Protein ID WP_000948331.1
Coordinates 2168483..2168653 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ60_RS11335 2165102..2165872 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
ELZ60_RS11340 2165847..2166326 - 480 WP_001190825.1 anti-sigma B factor RsbW -
ELZ60_RS11345 2166328..2166654 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ60_RS11350 2166773..2167774 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ60_RS11360 2168124..2168486 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ60_RS11365 2168483..2168653 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ60_RS11370 2168738..2169886 - 1149 WP_001281150.1 alanine racemase -
ELZ60_RS11375 2169952..2170311 - 360 WP_000581198.1 holo-ACP synthase -
ELZ60_RS11380 2170315..2170806 - 492 WP_001286982.1 PH domain-containing protein -
ELZ60_RS11385 2170799..2172376 - 1578 WP_126509085.1 PH domain-containing protein -
ELZ60_RS11390 2172369..2172848 - 480 WP_001287084.1 hypothetical protein -
ELZ60_RS11395 2173057..2173617 - 561 WP_001092415.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286739 WP_000621175.1 NZ_LR134090:c2168486-2168124 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286739 WP_000948331.1 NZ_LR134090:c2168653-2168483 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References