Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1949579..1950355 Replicon chromosome
Accession NZ_LR134090
Organism Staphylococcus aureus strain NCTC9555

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag ELZ60_RS09975 Protein ID WP_000031108.1
Coordinates 1949579..1949731 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag ELZ60_RS09980 Protein ID WP_001251219.1
Coordinates 1949756..1950355 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ60_RS09950 1945588..1946409 + 822 WP_000669385.1 RluA family pseudouridine synthase -
ELZ60_RS09955 1946860..1948245 - 1386 WP_000116236.1 class II fumarate hydratase -
ELZ60_RS09960 1948441..1948836 - 396 WP_000901023.1 hypothetical protein -
ELZ60_RS09975 1949579..1949731 - 153 WP_000031108.1 hypothetical protein Toxin
ELZ60_RS09980 1949756..1950355 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
ELZ60_RS09985 1950514..1950984 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ELZ60_RS09990 1950989..1952116 - 1128 WP_000379979.1 tRNA epoxyqueuosine(34) reductase QueG -
ELZ60_RS09995 1952267..1952989 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
ELZ60_RS10000 1952982..1954439 - 1458 WP_000649892.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T286738 WP_000031108.1 NZ_LR134090:c1949731-1949579 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT286738 WP_001251219.1 NZ_LR134090:c1950355-1949756 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References