Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1005406..1006212 Replicon chromosome
Accession NZ_LR134089
Organism Staphylococcus saprophyticus strain NCTC7666

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag ELZ48_RS04945 Protein ID WP_011302805.1
Coordinates 1006027..1006212 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A380HJZ2
Locus tag ELZ48_RS04940 Protein ID WP_002482876.1
Coordinates 1005406..1006005 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ48_RS04920 1001278..1002741 + 1464 WP_002482872.1 ABC transporter substrate-binding protein/permease -
ELZ48_RS04925 1002734..1003456 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
ELZ48_RS04930 1003617..1004744 + 1128 WP_002482874.1 tRNA epoxyqueuosine(34) reductase QueG -
ELZ48_RS04935 1004749..1005219 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ELZ48_RS04940 1005406..1006005 + 600 WP_002482876.1 glucosamine-6-phosphate isomerase Antitoxin
ELZ48_RS04945 1006027..1006212 + 186 WP_011302805.1 hypothetical protein Toxin
ELZ48_RS04950 1006369..1006785 + 417 WP_011302806.1 hypothetical protein -
ELZ48_RS04955 1007163..1008548 + 1386 WP_041080126.1 class II fumarate hydratase -
ELZ48_RS04960 1008751..1009578 - 828 WP_115338456.1 RluA family pseudouridine synthase -
ELZ48_RS04965 1009763..1010878 + 1116 WP_002482881.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T286730 WP_011302805.1 NZ_LR134089:1006027-1006212 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22294.12 Da        Isoelectric Point: 4.9719

>AT286730 WP_002482876.1 NZ_LR134089:1005406-1006005 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSSREVILIITGSNKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJZ2

References