Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VapB
Location 326685..327280 Replicon chromosome
Accession NC_019940
Organism Thioflavicoccus mobilis 8321

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag THIMO_RS01460 Protein ID WP_015279323.1
Coordinates 326882..327280 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag THIMO_RS01455 Protein ID WP_041603933.1
Coordinates 326685..326882 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THIMO_RS01440 321737..322807 - 1071 WP_051021972.1 carotenoid 1,2-hydratase -
THIMO_RS01445 323231..325762 - 2532 WP_015279320.1 ABC transporter permease -
THIMO_RS01450 325759..326448 - 690 WP_015279321.1 ABC transporter ATP-binding protein -
THIMO_RS01455 326685..326882 + 198 WP_041603933.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
THIMO_RS01460 326882..327280 + 399 WP_015279323.1 PIN domain nuclease Toxin
THIMO_RS01465 327621..328589 + 969 WP_015279324.1 2-hydroxyacid dehydrogenase -
THIMO_RS01470 329292..330239 + 948 WP_015279325.1 CRISPR system precrRNA processing endoribonuclease RAMP protein Cas6 -
THIMO_RS01475 330175..330888 - 714 WP_015279326.1 Uma2 family endonuclease -
THIMO_RS01480 331246..331551 - 306 WP_015279327.1 hypothetical protein -
THIMO_RS01485 331575..331979 - 405 WP_015279328.1 type II toxin-antitoxin system VapC family toxin -
THIMO_RS01490 331981..332223 - 243 WP_015279329.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14942.35 Da        Isoelectric Point: 6.3236

>T28673 WP_015279323.1 NC_019940:326882-327280 [Thioflavicoccus mobilis 8321]
MVLVDSSVWIDYFNGVPTAECDALDTLLGNELVLIGDLILTEVLQGFRTDAAYRQARTLLEPLTLCRLGGRKIALAAADH
YRYLRRRGVTVRKTIDVIIASYCLLHDVELLHVDRDFDAIEQHLGLRVHRLV

Download         Length: 399 bp

>T28673 NC_019940:326882-327280 [Thioflavicoccus mobilis 8321]
ATGGTCTTGGTCGACTCGTCGGTCTGGATCGACTACTTCAACGGGGTTCCCACCGCCGAATGCGATGCGCTCGACACCCT
GCTCGGCAATGAATTGGTACTGATCGGCGACCTGATCCTGACCGAGGTGCTGCAAGGCTTCCGCACCGATGCCGCTTACA
GGCAAGCGCGGACCTTGCTCGAGCCGCTGACTCTTTGTCGTCTCGGAGGACGAAAGATTGCCTTGGCCGCGGCCGATCAC
TATCGATACCTGCGCCGCCGAGGCGTGACGGTACGCAAGACGATCGACGTCATCATTGCGAGCTATTGTCTTTTGCACGA
CGTGGAACTCCTTCACGTAGATCGGGATTTCGACGCCATCGAGCAGCACCTCGGCCTTCGGGTTCATCGACTCGTATAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7611.70 Da        Isoelectric Point: 6.3543

>AT28673 WP_041603933.1 NC_019940:326685-326882 [Thioflavicoccus mobilis 8321]
MRTNIVIDDQLMERALAASGYRTKREAVEEGLRLLVRLKEQERIRAARGKLPWDGDLEAMRRDDE

Download         Length: 198 bp

>AT28673 NC_019940:326685-326882 [Thioflavicoccus mobilis 8321]
ATGCGTACGAACATCGTCATCGATGACCAACTGATGGAGCGCGCGCTCGCCGCCTCTGGATATCGGACGAAGCGGGAAGC
CGTCGAGGAAGGTCTTCGCCTCCTGGTGCGACTCAAAGAACAGGAACGAATCCGAGCGGCTCGCGGCAAGCTGCCCTGGG
ACGGAGATCTCGAAGCCATGCGGCGTGACGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References