Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 867818..868347 Replicon chromosome
Accession NZ_LR134089
Organism Staphylococcus saprophyticus strain NCTC7666

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ48_RS04150 Protein ID WP_002482752.1
Coordinates 867985..868347 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A380HJK7
Locus tag ELZ48_RS04145 Protein ID WP_037538046.1
Coordinates 867818..867988 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ48_RS04120 863549..864028 + 480 WP_002482747.1 PH domain-containing protein -
ELZ48_RS04125 864021..865559 + 1539 WP_115338429.1 PH domain-containing protein -
ELZ48_RS04130 865552..866052 + 501 WP_002482749.1 PH domain-containing protein -
ELZ48_RS04135 866116..866466 + 351 WP_002482750.1 holo-ACP synthase -
ELZ48_RS04140 866582..867730 + 1149 WP_002482751.1 alanine racemase -
ELZ48_RS04145 867818..867988 + 171 WP_037538046.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ48_RS04150 867985..868347 + 363 WP_002482752.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ48_RS04155 868684..869685 + 1002 WP_041080774.1 PP2C family protein-serine/threonine phosphatase -
ELZ48_RS04160 869764..870090 + 327 WP_011302705.1 anti-sigma factor antagonist -
ELZ48_RS04165 870092..870574 + 483 WP_115338431.1 anti-sigma B factor RsbW -
ELZ48_RS04170 870549..871308 + 760 Protein_822 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13498.70 Da        Isoelectric Point: 10.3173

>T286729 WP_002482752.1 NZ_LR134089:867985-868347 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6304.97 Da        Isoelectric Point: 4.0121

>AT286729 WP_037538046.1 NZ_LR134089:867818-867988 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJK7

References