Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 856148..856662 Replicon chromosome
Accession NZ_LR134089
Organism Staphylococcus saprophyticus strain NCTC7666

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag ELZ48_RS04090 Protein ID WP_002482741.1
Coordinates 856456..856662 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag ELZ48_RS04085 Protein ID WP_002482740.1
Coordinates 856148..856441 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ48_RS04060 851310..852101 + 792 WP_002482735.1 hydroxyethylthiazole kinase -
ELZ48_RS04065 852101..852739 + 639 WP_002482736.1 thiamine phosphate synthase -
ELZ48_RS04070 852827..853696 + 870 WP_002482737.1 membrane protein insertase YidC -
ELZ48_RS04075 853778..854425 - 648 WP_037538041.1 HD domain-containing protein -
ELZ48_RS04080 854521..856005 - 1485 WP_011302692.1 cardiolipin synthase -
ELZ48_RS04085 856148..856441 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
ELZ48_RS04090 856456..856662 + 207 WP_002482741.1 hypothetical protein Toxin
ELZ48_RS04095 856875..857015 + 141 WP_002482742.1 hypothetical protein -
ELZ48_RS04100 857308..858513 - 1206 WP_011302694.1 rod shape-determining protein RodA -
ELZ48_RS04105 858762..859832 + 1071 WP_002482744.1 D-alanine--D-alanine ligase -
ELZ48_RS04110 859845..861200 + 1356 WP_002482745.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T286728 WP_002482741.1 NZ_LR134089:856456-856662 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT286728 WP_002482740.1 NZ_LR134089:856148-856441 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References