Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2181240..2181754 Replicon chromosome
Accession NZ_LR134087
Organism Staphylococcus aureus strain NCTC7121

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ELZ50_RS11335 Protein ID WP_000581792.1
Coordinates 2181240..2181449 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ELZ50_RS11340 Protein ID WP_000138932.1
Coordinates 2181461..2181754 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ50_RS11315 2176748..2178106 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ELZ50_RS11320 2178121..2179191 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ELZ50_RS11325 2179509..2180711 + 1203 WP_001836940.1 rod shape-determining protein RodA -
ELZ50_RS11330 2180975..2181112 - 138 WP_000828354.1 hypothetical protein -
ELZ50_RS11335 2181240..2181449 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ELZ50_RS11340 2181461..2181754 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ELZ50_RS11345 2181920..2183404 + 1485 WP_000571549.1 cardiolipin synthase -
ELZ50_RS11350 2183432..2184079 + 648 WP_001187630.1 HD domain-containing protein -
ELZ50_RS11365 2184684..2185556 - 873 WP_000725802.1 membrane protein insertase YidC -
ELZ50_RS11370 2185642..2186283 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T286724 WP_000581792.1 NZ_LR134087:c2181449-2181240 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT286724 WP_000138932.1 NZ_LR134087:c2181754-2181461 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References