Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2161486..2162015 Replicon chromosome
Accession NZ_LR134087
Organism Staphylococcus aureus strain NCTC7121

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ50_RS11245 Protein ID WP_000621175.1
Coordinates 2161486..2161848 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ50_RS11250 Protein ID WP_000948331.1
Coordinates 2161845..2162015 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ50_RS11220 2158464..2159234 - 771 Protein_2074 RNA polymerase sigma factor SigB -
ELZ50_RS11225 2159209..2159688 - 480 WP_001190829.1 anti-sigma B factor RsbW -
ELZ50_RS11230 2159690..2160016 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ50_RS11235 2160135..2161136 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ50_RS11245 2161486..2161848 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ50_RS11250 2161845..2162015 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ50_RS11255 2162100..2163248 - 1149 WP_001281154.1 alanine racemase -
ELZ50_RS11260 2163314..2163673 - 360 WP_000581197.1 holo-ACP synthase -
ELZ50_RS11265 2163677..2164168 - 492 WP_001205912.1 PH domain-containing protein -
ELZ50_RS11270 2164155..2165738 - 1584 WP_001294620.1 PH domain-containing protein -
ELZ50_RS11275 2165731..2166210 - 480 WP_001836941.1 hypothetical protein -
ELZ50_RS11280 2166419..2166979 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286723 WP_000621175.1 NZ_LR134087:c2161848-2161486 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286723 WP_000948331.1 NZ_LR134087:c2162015-2161845 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References