Detailed information of TA system TA028672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 35165..35847
• Replicon: chromosome
• Accession: NC_019940
• Organism: Thioflavicoccus mobilis 8321

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: L0GU65
• Locus tag: THIMO_RS00165
• Protein ID: WP_015279065.1
• Coordinates: 35165..35599 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0GSE5
• Locus tag: THIMO_RS00170
• Protein ID: WP_015279066.1
• Coordinates: 35599..35847 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIMO_RS00135	31447..31851	-	405	WP_015279059.1	type II toxin-antitoxin system VapC family toxin	-
THIMO_RS00140	31848..32096	-	249	WP_015279060.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
THIMO_RS00145	32167..32388	-	222	WP_015279061.1	hypothetical protein	-
THIMO_RS00150	32607..33188	-	582	WP_015279062.1	acetyltransferase	-
THIMO_RS00155	33198..34148	-	951	WP_015279063.1	Gfo/Idh/MocA family oxidoreductase	-
THIMO_RS00160	34961..35164	-	204	WP_015279064.1	hypothetical protein	-
THIMO_RS00165	35165..35599	-	435	WP_015279065.1	PIN domain-containing protein	Toxin
THIMO_RS00170	35599..35847	-	249	WP_015279066.1	hypothetical protein	Antitoxin
THIMO_RS00175	36332..37216	-	885	WP_015279067.1	metal ABC transporter permease	-
THIMO_RS00180	37255..38004	-	750	WP_015279068.1	ABC transporter ATP-binding protein	-
THIMO_RS00185	38001..38924	-	924	WP_015279069.1	zinc ABC transporter substrate-binding protein	-
THIMO_RS00190	39154..40137	-	984	WP_015279070.1	HPr(Ser) kinase/phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	bplB	17454..35847	18393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16000.43 Da
• Isoelectric Point: 7.0286

>T28672 WP_015279065.1 NC_019940:c35599-35165 [Thioflavicoccus mobilis 8321]
VRALLDINVIIALLDAGHVMHRAAKYWLAREVEQGWATCPITQNGVLRIMSQPAYPNARPVAQVAARLQEACNHPSHQFW
PEEISLLGDGVIRWDRILGHRQITDAFLLALAAARGGRFVSFDRRIHTDLVCAAEAENLCVIDG

Nucleotide

• Length: 435 bp

>T28672 NC_019940:c35599-35165 [Thioflavicoccus mobilis 8321]
GTGCGGGCACTGCTCGATATCAATGTGATCATCGCGCTGCTCGATGCTGGGCACGTGATGCATCGAGCTGCGAAATATTG
GTTAGCGCGCGAGGTCGAACAGGGCTGGGCAACCTGTCCGATCACCCAGAACGGCGTGCTGCGGATCATGTCTCAGCCCG
CCTATCCCAATGCGCGGCCGGTCGCACAGGTCGCTGCGCGCTTGCAGGAGGCCTGCAACCATCCGAGTCATCAGTTCTGG
CCGGAAGAGATCAGTCTGTTGGGCGATGGTGTGATCCGGTGGGATCGAATCCTGGGACACCGACAGATCACCGATGCCTT
CCTGTTGGCTCTGGCAGCAGCGCGCGGCGGTCGCTTCGTAAGCTTCGACCGGCGGATCCACACGGACCTCGTATGTGCGG
CTGAGGCGGAGAATCTCTGCGTGATCGATGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8729.83 Da
• Isoelectric Point: 4.6721

>AT28672 WP_015279066.1 NC_019940:c35847-35599 [Thioflavicoccus mobilis 8321]
MRTTLDIEDDVLQAAKELARQQKVSAGKVISQLLRAALSGVPADDAPNAQAASVAGFRPFAAEGQRLVTNAQIEQLRDQE
GL

Nucleotide

• Length: 249 bp

>AT28672 NC_019940:c35847-35599 [Thioflavicoccus mobilis 8321]
ATGCGCACCACGCTGGATATTGAAGACGACGTCTTGCAGGCGGCCAAGGAGCTGGCCCGGCAACAAAAAGTGTCTGCCGG
AAAGGTGATCTCGCAGTTGCTTCGCGCCGCATTGTCAGGGGTGCCGGCGGATGATGCGCCAAATGCTCAGGCCGCGAGCG
TCGCCGGCTTTCGTCCCTTCGCAGCAGAGGGACAGAGGCTGGTGACCAACGCCCAGATCGAACAATTACGGGATCAGGAG
GGCCTTTAG

Structures

Toxin

• AlphaFold DB: L0GU65

Antitoxin

• AlphaFold DB: L0GSE5