286712

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2181875..2182389 Replicon chromosome
Accession NZ_LR134086
Organism Staphylococcus aureus strain NCTC13142

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ELZ49_RS11220 Protein ID WP_000581792.1
Coordinates 2181875..2182084 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag ELZ49_RS11225 Protein ID WP_000138928.1
Coordinates 2182096..2182389 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ49_RS11200 2177383..2178741 - 1359 WP_000611469.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ELZ49_RS11205 2178756..2179826 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
ELZ49_RS11210 2180144..2181346 + 1203 WP_001109944.1 rod shape-determining protein RodA -
ELZ49_RS11215 2181610..2181747 - 138 WP_000828354.1 hypothetical protein -
ELZ49_RS11220 2181875..2182084 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ELZ49_RS11225 2182096..2182389 - 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
ELZ49_RS11230 2182555..2184039 + 1485 WP_000571551.1 cardiolipin synthase -
ELZ49_RS11235 2184067..2184714 + 648 WP_001187617.1 HD domain-containing protein -
ELZ49_RS11245 2185192..2186064 - 873 WP_000725802.1 membrane protein insertase YidC -
ELZ49_RS11250 2186150..2186791 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T286712 WP_000581792.1 NZ_LR134086:c2182084-2181875 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT286712 WP_000138928.1 NZ_LR134086:c2182389-2182096 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References