286711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2162120..2162649 Replicon chromosome
Accession NZ_LR134086
Organism Staphylococcus aureus strain NCTC13142

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ49_RS11130 Protein ID WP_000621175.1
Coordinates 2162120..2162482 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ELZ49_RS11135 Protein ID WP_000948330.1
Coordinates 2162479..2162649 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ49_RS11105 2159098..2159868 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
ELZ49_RS11110 2159843..2160322 - 480 WP_001190825.1 anti-sigma B factor RsbW -
ELZ49_RS11115 2160324..2160650 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ49_RS11120 2160770..2161771 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ49_RS11130 2162120..2162482 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ49_RS11135 2162479..2162649 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ49_RS11140 2162734..2163882 - 1149 WP_001281141.1 alanine racemase -
ELZ49_RS11145 2163948..2164307 - 360 WP_000581193.1 holo-ACP synthase -
ELZ49_RS11150 2164311..2164802 - 492 WP_001205918.1 PH domain-containing protein -
ELZ49_RS11155 2164789..2166372 - 1584 WP_001294624.1 PH domain-containing protein -
ELZ49_RS11160 2166365..2166844 - 480 WP_001287080.1 hypothetical protein -
ELZ49_RS11165 2167053..2167613 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286711 WP_000621175.1 NZ_LR134086:c2162482-2162120 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT286711 WP_000948330.1 NZ_LR134086:c2162649-2162479 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References