Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2161859..2162388 Replicon chromosome
Accession NZ_LR134085
Organism Staphylococcus aureus strain NCTC12233

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ52_RS11325 Protein ID WP_000621175.1
Coordinates 2161859..2162221 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ52_RS11330 Protein ID WP_000948331.1
Coordinates 2162218..2162388 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ52_RS11300 2158837..2159607 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
ELZ52_RS11305 2159582..2160061 - 480 WP_001190829.1 anti-sigma B factor RsbW -
ELZ52_RS11310 2160063..2160389 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ52_RS11315 2160508..2161509 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ELZ52_RS11325 2161859..2162221 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ52_RS11330 2162218..2162388 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ52_RS11335 2162473..2163621 - 1149 WP_001281145.1 alanine racemase -
ELZ52_RS11340 2163687..2164046 - 360 WP_000581200.1 holo-ACP synthase -
ELZ52_RS11345 2164050..2164541 - 492 WP_001205910.1 PH domain-containing protein -
ELZ52_RS11350 2164528..2166111 - 1584 WP_001294626.1 PH domain-containing protein -
ELZ52_RS11355 2166104..2166583 - 480 WP_001287088.1 hypothetical protein -
ELZ52_RS11360 2166791..2167351 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286694 WP_000621175.1 NZ_LR134085:c2162221-2161859 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286694 WP_000948331.1 NZ_LR134085:c2162388-2162218 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References