Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431027..3431645 Replicon chromosome
Accession NZ_LR134082
Organism Escherichia coli strain NCTC9038

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL018_RS16750 Protein ID WP_001291435.1
Coordinates 3431427..3431645 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL018_RS16745 Protein ID WP_000344800.1
Coordinates 3431027..3431401 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL018_RS16735 3426117..3427310 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL018_RS16740 3427333..3430481 + 3149 Protein_3242 efflux RND transporter permease AcrB -
EL018_RS16745 3431027..3431401 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL018_RS16750 3431427..3431645 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL018_RS16755 3431817..3432368 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL018_RS16760 3432484..3432954 + 471 WP_000136192.1 YlaC family protein -
EL018_RS16765 3433118..3434668 + 1551 WP_032265872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL018_RS16770 3434710..3435063 - 354 WP_000878140.1 DUF1428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286681 WP_001291435.1 NZ_LR134082:3431427-3431645 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286681 WP_000344800.1 NZ_LR134082:3431027-3431401 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References