Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2414776..2415414 Replicon chromosome
Accession NZ_LR134082
Organism Escherichia coli strain NCTC9038

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL018_RS11795 Protein ID WP_000813794.1
Coordinates 2415238..2415414 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL018_RS11790 Protein ID WP_001270286.1
Coordinates 2414776..2415192 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL018_RS11770 2409929..2410869 - 941 Protein_2282 ABC transporter permease -
EL018_RS11775 2410870..2411883 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL018_RS11780 2411901..2413046 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL018_RS11785 2413291..2414697 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL018_RS11790 2414776..2415192 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL018_RS11795 2415238..2415414 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL018_RS11800 2415636..2415866 + 231 WP_000494244.1 YncJ family protein -
EL018_RS11805 2415958..2417919 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL018_RS11810 2417992..2418528 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EL018_RS11815 2418581..2419795 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T286680 WP_000813794.1 NZ_LR134082:c2415414-2415238 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T286680 NZ_LR134082:c2415414-2415238 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT286680 WP_001270286.1 NZ_LR134082:c2415192-2414776 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT286680 NZ_LR134082:c2415192-2414776 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References