Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2242708..2243234 Replicon chromosome
Accession NZ_LR134082
Organism Escherichia coli strain NCTC9038

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL018_RS10925 Protein ID WP_000323025.1
Coordinates 2242947..2243234 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL018_RS10920 Protein ID WP_000534858.1
Coordinates 2242708..2242947 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL018_RS10885 2237822..2238073 + 252 Protein_2109 DUF977 family protein -
EL018_RS10890 2238070..2238426 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL018_RS22835 2239037..2239324 + 288 Protein_2111 hypothetical protein -
EL018_RS10905 2240093..2241406 + 1314 WP_000589005.1 ISNCY family transposase -
EL018_RS10910 2241843..2242175 - 333 WP_001301033.1 protein FlxA -
EL018_RS10915 2242378..2242683 - 306 WP_001326990.1 hypothetical protein -
EL018_RS10920 2242708..2242947 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL018_RS10925 2242947..2243234 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL018_RS10930 2243306..2243461 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL018_RS10935 2243678..2243929 + 252 WP_000980994.1 hypothetical protein -
EL018_RS10940 2243996..2244274 + 279 WP_012304870.1 hypothetical protein -
EL018_RS10945 2244276..2245325 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL018_RS10950 2245339..2246091 + 753 WP_001047135.1 antitermination protein -
EL018_RS10955 2246369..2246458 - 90 WP_120795389.1 hypothetical protein -
EL018_RS10960 2246513..2246725 - 213 WP_000087756.1 cold shock-like protein CspF -
EL018_RS10965 2247026..2247241 + 216 WP_000066484.1 cold shock-like protein CspB -
EL018_RS22980 2247605..2247775 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL018_RS10970 2247995..2248210 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2214709..2258512 43803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286679 WP_000323025.1 NZ_LR134082:2242947-2243234 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286679 WP_000534858.1 NZ_LR134082:2242708-2242947 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References