Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1414994..1415619 Replicon chromosome
Accession NZ_LR134080
Organism Escherichia coli strain NCTC9082

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL023_RS06980 Protein ID WP_000911330.1
Coordinates 1415221..1415619 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL023_RS06975 Protein ID WP_000450524.1
Coordinates 1414994..1415221 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL023_RS06950 1410797..1411267 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
EL023_RS06955 1411267..1411839 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL023_RS06960 1411985..1412863 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL023_RS06965 1412880..1413914 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL023_RS06970 1414127..1414840 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL023_RS06975 1414994..1415221 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL023_RS06980 1415221..1415619 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL023_RS06985 1415766..1416629 + 864 WP_001267508.1 neutral zinc metallopeptidase -
EL023_RS06990 1416644..1418659 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
EL023_RS06995 1418733..1419431 + 699 WP_000679823.1 esterase -
EL023_RS07000 1419541..1419741 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T286652 WP_000911330.1 NZ_LR134080:1415221-1415619 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT286652 WP_000450524.1 NZ_LR134080:1414994-1415221 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References