Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4014811..4015429 Replicon chromosome
Accession NZ_LR134079
Organism Escherichia coli strain NCTC9112

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL053_RS20105 Protein ID WP_001291435.1
Coordinates 4015211..4015429 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL053_RS20100 Protein ID WP_000344800.1
Coordinates 4014811..4015185 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL053_RS20090 4009900..4011093 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL053_RS20095 4011116..4014265 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL053_RS20100 4014811..4015185 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL053_RS20105 4015211..4015429 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL053_RS20110 4015601..4016152 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL053_RS20115 4016268..4016738 + 471 WP_000136192.1 YlaC family protein -
EL053_RS20120 4016902..4018452 + 1551 WP_001362407.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL053_RS20125 4018494..4018847 - 354 WP_000878146.1 DUF1428 family protein -
EL053_RS20135 4019226..4019537 + 312 WP_000409914.1 MGMT family protein -
EL053_RS20140 4019568..4020140 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286640 WP_001291435.1 NZ_LR134079:4015211-4015429 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT286640 WP_000344800.1 NZ_LR134079:4014811-4015185 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References