Detailed information of TA system TA028664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3286712..3287199
• Replicon: chromosome
• Accession: NC_019903
• Organism: Desulfitobacterium dichloroeliminans LMG P-21439

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DESDI_RS15625
• Protein ID: WP_015263578.1
• Coordinates: 3286712..3286978 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L0FC89
• Locus tag: DESDI_RS15630
• Protein ID: WP_015263579.1
• Coordinates: 3286978..3287199 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESDI_RS15615	3282422..3284083	-	1662	WP_083879880.1	N-acetylmuramoyl-L-alanine amidase	-
DESDI_RS15620	3284585..3286645	+	2061	WP_015263577.1	cell wall-binding repeat-containing protein	-
DESDI_RS15625	3286712..3286978	-	267	WP_015263578.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DESDI_RS15630	3286978..3287199	-	222	WP_015263579.1	CopG family transcriptional regulator	Antitoxin
DESDI_RS15635	3287466..3288578	+	1113	WP_015263580.1	DegT/DnrJ/EryC1/StrS family aminotransferase	-
DESDI_RS15640	3288612..3289943	+	1332	WP_015263581.1	O-antigen ligase family protein	-
DESDI_RS17960	3289940..3290053	+	114	Protein_3081	glycosyltransferase WbuB	-
DESDI_RS17965	3290513..3291331	+	819	WP_156801190.1	glycosyltransferase family 4 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (2-70)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10190.92 Da
• Isoelectric Point: 10.2271

>T28664 WP_015263578.1 NC_019903:c3286978-3286712 [Desulfitobacterium dichloroeliminans LMG P-21439]
MYHVVLTEGAKKEIKNMDRPTALLILAWIRKNLEGCENPRLHGKALKGNLDSRWSYRVGDYRLLAEIQDSKITLLIVSIG
HRREVYKS

Nucleotide

• Length: 267 bp

>T28664 NC_019903:c3286978-3286712 [Desulfitobacterium dichloroeliminans LMG P-21439]
ATGTATCACGTCGTCCTTACTGAAGGAGCCAAAAAGGAAATAAAAAATATGGATAGACCGACGGCCCTTCTTATTCTGGC
TTGGATACGCAAGAATTTGGAGGGGTGCGAGAATCCCCGTCTCCACGGCAAAGCGCTTAAGGGCAATTTAGACAGTAGAT
GGAGTTATCGGGTGGGCGATTATCGTTTGCTTGCTGAGATACAGGATAGTAAAATCACCCTATTAATAGTGAGTATCGGC
CATAGAAGAGAGGTATATAAAAGCTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8415.63 Da
• Isoelectric Point: 4.3822

>AT28664 WP_015263579.1 NC_019903:c3287199-3286978 [Desulfitobacterium dichloroeliminans LMG P-21439]
MTISIRLSPAEAELIKSYATLKKQSVSDVMRKAILEQIEDEYDLEVYEKAMAEYRKNPVTYSLEEVEKELGLS

Nucleotide

• Length: 222 bp

>AT28664 NC_019903:c3287199-3286978 [Desulfitobacterium dichloroeliminans LMG P-21439]
ATGACGATTTCTATTCGACTGAGTCCTGCAGAAGCAGAACTCATTAAGAGTTATGCAACATTAAAAAAACAAAGCGTATC
TGATGTTATGAGGAAAGCAATCCTTGAGCAGATCGAAGATGAATATGATCTTGAAGTATATGAAAAAGCAATGGCCGAAT
ATCGTAAAAATCCCGTGACTTACTCGCTAGAGGAAGTTGAAAAGGAACTGGGTTTAAGCTGA

Structures

Antitoxin

• AlphaFold DB: L0FC89