Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2824403..2824929 Replicon chromosome
Accession NZ_LR134079
Organism Escherichia coli strain NCTC9112

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL053_RS14100 Protein ID WP_000323025.1
Coordinates 2824403..2824690 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL053_RS14105 Protein ID WP_000534858.1
Coordinates 2824690..2824929 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL053_RS14055 2819427..2819642 - 216 WP_000839590.1 phage lysis protein EssD -
EL053_RS27540 2819862..2820032 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL053_RS14060 2820396..2820611 - 216 WP_000066484.1 cold shock-like protein CspB -
EL053_RS14065 2820912..2821124 + 213 WP_000087756.1 cold shock-like protein CspF -
EL053_RS14070 2821179..2821268 + 90 WP_120795389.1 hypothetical protein -
EL053_RS14075 2821546..2822298 - 753 WP_001047135.1 antitermination protein -
EL053_RS14080 2822312..2823361 - 1050 WP_001265198.1 DUF968 domain-containing protein -
EL053_RS14085 2823363..2823641 - 279 WP_012304870.1 hypothetical protein -
EL053_RS14090 2823708..2823959 - 252 WP_000980994.1 hypothetical protein -
EL053_RS14095 2824176..2824331 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL053_RS14100 2824403..2824690 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL053_RS14105 2824690..2824929 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL053_RS14110 2824954..2825259 + 306 WP_001326990.1 hypothetical protein -
EL053_RS14115 2825463..2825774 + 312 Protein_2726 FlxA-like family protein -
EL053_RS14120 2825810..2827018 - 1209 WP_000343717.1 IS256 family transposase -
EL053_RS14125 2827555..2828868 - 1314 WP_114493669.1 ISNCY family transposase -
EL053_RS27405 2829637..2829924 - 288 Protein_2729 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2789039..2851836 62797
- inside Prophage - - 2786388..2851836 65448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286638 WP_000323025.1 NZ_LR134079:c2824690-2824403 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286638 WP_000534858.1 NZ_LR134079:c2824929-2824690 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References