Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2660201..2660839 Replicon chromosome
Accession NZ_LR134079
Organism Escherichia coli strain NCTC9112

Toxin (Protein)


Gene name hicA Uniprot ID A0A080J2T0
Locus tag EL053_RS13325 Protein ID WP_000813793.1
Coordinates 2660201..2660377 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL053_RS13330 Protein ID WP_001270286.1
Coordinates 2660423..2660839 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL053_RS13305 2655823..2657034 - 1212 WP_023154256.1 BenE family transporter YdcO -
EL053_RS13310 2657087..2657623 + 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
EL053_RS13315 2657696..2659657 + 1962 WP_024257894.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL053_RS13320 2659749..2659979 - 231 WP_000494244.1 YncJ family protein -
EL053_RS13325 2660201..2660377 + 177 WP_000813793.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL053_RS13330 2660423..2660839 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL053_RS13335 2660918..2662324 + 1407 WP_000760655.1 PLP-dependent aminotransferase family protein -
EL053_RS13340 2662569..2663714 + 1146 WP_000047419.1 ABC transporter substrate-binding protein -
EL053_RS13345 2663732..2664745 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
EL053_RS13350 2664746..2665687 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.83 Da        Isoelectric Point: 10.9223

>T286636 WP_000813793.1 NZ_LR134079:2660201-2660377 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGMRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT286636 WP_001270286.1 NZ_LR134079:2660423-2660839 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A080J2T0

Antitoxin

Source ID Structure

References