Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1146856..1147439 Replicon chromosome
Accession NZ_LR134079
Organism Escherichia coli strain NCTC9112

Toxin (Protein)


Gene name mazF Uniprot ID U9Y5H3
Locus tag EL053_RS05620 Protein ID WP_000254735.1
Coordinates 1147104..1147439 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U9Y5F1
Locus tag EL053_RS05615 Protein ID WP_000581936.1
Coordinates 1146856..1147104 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL053_RS05605 1143195..1144496 + 1302 WP_000046797.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
EL053_RS05610 1144544..1146778 + 2235 WP_000226815.1 GTP pyrophosphokinase -
EL053_RS05615 1146856..1147104 + 249 WP_000581936.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL053_RS05620 1147104..1147439 + 336 WP_000254735.1 endoribonuclease MazF Toxin
EL053_RS05625 1147511..1148302 + 792 WP_001071673.1 nucleoside triphosphate pyrophosphohydrolase -
EL053_RS05630 1148530..1150167 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
EL053_RS05635 1150255..1151553 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12070.03 Da        Isoelectric Point: 8.2605

>T286629 WP_000254735.1 NZ_LR134079:1147104-1147439 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRAKGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9341.71 Da        Isoelectric Point: 4.4536

>AT286629 WP_000581936.1 NZ_LR134079:1146856-1147104 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHDNIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Y5H3

Antitoxin

Source ID Structure
AlphaFold DB U9Y5F1

References