Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3947199..3948013 Replicon chromosome
Accession NZ_LR134075
Organism Escherichia coli strain NCTC9084

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EL019_RS19280 Protein ID WP_001054376.1
Coordinates 3947199..3947456 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag EL019_RS19285 Protein ID WP_001309181.1
Coordinates 3947468..3948013 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL019_RS19260 3942487..3943593 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
EL019_RS19265 3943658..3944638 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL019_RS19270 3945221..3946461 - 1241 Protein_3732 helicase YjhR -
EL019_RS19275 3946577..3946822 + 246 Protein_3733 GNAT family N-acetyltransferase -
EL019_RS19280 3947199..3947456 + 258 WP_001054376.1 hypothetical protein Toxin
EL019_RS19285 3947468..3948013 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
EL019_RS19290 3948069..3948815 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EL019_RS19295 3948984..3949202 + 219 Protein_3737 hypothetical protein -
EL019_RS22550 3949240..3949356 + 117 Protein_3738 VOC family protein -
EL019_RS19300 3949601..3950722 + 1122 WP_000010829.1 M42 family metallopeptidase -
EL019_RS19305 3950719..3950997 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EL019_RS19310 3951009..3952322 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 3939692..3956237 16545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T286622 WP_001054376.1 NZ_LR134075:3947199-3947456 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT286622 WP_001309181.1 NZ_LR134075:3947468-3948013 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References