Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2229649..2230175 Replicon chromosome
Accession NZ_LR134075
Organism Escherichia coli strain NCTC9084

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL019_RS10895 Protein ID WP_000323025.1
Coordinates 2229888..2230175 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL019_RS10890 Protein ID WP_000534858.1
Coordinates 2229649..2229888 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL019_RS10855 2224763..2225014 + 252 Protein_2095 DUF977 family protein -
EL019_RS10860 2225011..2225367 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL019_RS22505 2225978..2226265 + 288 Protein_2097 hypothetical protein -
EL019_RS10875 2227034..2228347 + 1314 WP_000589005.1 ISNCY family transposase -
EL019_RS10880 2228784..2229116 - 333 WP_001301033.1 protein FlxA -
EL019_RS10885 2229319..2229624 - 306 WP_001326990.1 hypothetical protein -
EL019_RS10890 2229649..2229888 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL019_RS10895 2229888..2230175 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL019_RS10900 2230247..2230402 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL019_RS10905 2230619..2230870 + 252 WP_000980994.1 hypothetical protein -
EL019_RS10910 2230937..2231215 + 279 WP_012304870.1 hypothetical protein -
EL019_RS10915 2231217..2232176 + 960 Protein_2106 HNH endonuclease -
EL019_RS22510 2232177..2232269 + 93 Protein_2107 antitermination protein -
EL019_RS10920 2232547..2232636 - 90 WP_120795389.1 hypothetical protein -
EL019_RS10925 2232691..2232903 - 213 WP_000087756.1 cold shock-like protein CspF -
EL019_RS10930 2233204..2233419 + 216 WP_000066484.1 cold shock-like protein CspB -
EL019_RS22630 2233783..2233953 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL019_RS10935 2234173..2234388 + 216 WP_000839590.1 phage lysis protein EssD -
EL019_RS10940 2234393..2234704 + 312 WP_000189916.1 YdfR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2206908..2250277 43369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286615 WP_000323025.1 NZ_LR134075:2229888-2230175 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286615 WP_000534858.1 NZ_LR134075:2229649-2229888 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References