286615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2229649..2230175 Replicon chromosome
Accession NZ_LR134075
Organism Escherichia coli strain NCTC9084

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL019_RS10895 Protein ID WP_000323025.1
Coordinates 2229888..2230175 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL019_RS10890 Protein ID WP_000534858.1
Coordinates 2229649..2229888 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL019_RS10855 2224763..2225014 + 252 Protein_2095 DUF977 family protein -
EL019_RS10860 2225011..2225367 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL019_RS22505 2225978..2226265 + 288 Protein_2097 hypothetical protein -
EL019_RS10875 2227034..2228347 + 1314 WP_000589005.1 ISNCY family transposase -
EL019_RS10880 2228784..2229116 - 333 WP_001301033.1 protein FlxA -
EL019_RS10885 2229319..2229624 - 306 WP_001326990.1 hypothetical protein -
EL019_RS10890 2229649..2229888 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL019_RS10895 2229888..2230175 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL019_RS10900 2230247..2230402 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL019_RS10905 2230619..2230870 + 252 WP_000980994.1 hypothetical protein -
EL019_RS10910 2230937..2231215 + 279 WP_012304870.1 hypothetical protein -
EL019_RS10915 2231217..2232176 + 960 Protein_2106 HNH endonuclease -
EL019_RS22510 2232177..2232269 + 93 Protein_2107 antitermination protein -
EL019_RS10920 2232547..2232636 - 90 WP_120795389.1 hypothetical protein -
EL019_RS10925 2232691..2232903 - 213 WP_000087756.1 cold shock-like protein CspF -
EL019_RS10930 2233204..2233419 + 216 WP_000066484.1 cold shock-like protein CspB -
EL019_RS22630 2233783..2233953 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL019_RS10935 2234173..2234388 + 216 WP_000839590.1 phage lysis protein EssD -
EL019_RS10940 2234393..2234704 + 312 WP_000189916.1 YdfR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2206908..2250277 43369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T286615 WP_000323025.1 NZ_LR134075:2229888-2230175 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT286615 WP_000534858.1 NZ_LR134075:2229649-2229888 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References