Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4442139..4442636 Replicon chromosome
Accession NZ_LR134031
Organism Escherichia coli strain NCTC11151

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag EL024_RS22195 Protein ID WP_001173343.1
Coordinates 4442139..4442312 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag EL024_RS22200 Protein ID WP_001312331.1
Coordinates 4442340..4442636 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL024_RS22185 4438809..4440266 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
EL024_RS22190 4440503..4442020 + 1518 WP_000003806.1 lysine--tRNA ligase -
EL024_RS22195 4442139..4442312 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
EL024_RS22200 4442340..4442636 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
EL024_RS22205 4442865..4443137 - 273 WP_000405647.1 N-acetyltransferase -
EL024_RS22210 4443149..4443379 - 231 WP_000373293.1 (4Fe-4S)-binding protein -
EL024_RS22215 4443560..4445191 + 1632 WP_001216482.1 sensor histidine kinase -
EL024_RS22220 4445188..4445907 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T286602 WP_001173343.1 NZ_LR134031:c4442312-4442139 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT286602 WP_001312331.1 NZ_LR134031:c4442636-4442340 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References