Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4215952..4216766 Replicon chromosome
Accession NZ_LR134031
Organism Escherichia coli strain NCTC11151

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag EL024_RS21015 Protein ID WP_001054376.1
Coordinates 4215952..4216209 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A8E0IVE5
Locus tag EL024_RS21020 Protein ID WP_001350781.1
Coordinates 4216221..4216766 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL024_RS20995 4211240..4212346 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
EL024_RS21000 4212411..4213391 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
EL024_RS21005 4213974..4215214 - 1241 Protein_4048 helicase YjhR -
EL024_RS21010 4215330..4215575 + 246 Protein_4049 GNAT family N-acetyltransferase -
EL024_RS21015 4215952..4216209 + 258 WP_001054376.1 hypothetical protein Toxin
EL024_RS21020 4216221..4216766 + 546 WP_001350781.1 N-acetyltransferase Antitoxin
EL024_RS21025 4216822..4217568 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
EL024_RS21030 4217737..4217955 + 219 Protein_4053 hypothetical protein -
EL024_RS24825 4217993..4218109 + 117 Protein_4054 VOC family protein -
EL024_RS21035 4218354..4219475 + 1122 WP_000010829.1 M42 family metallopeptidase -
EL024_RS21040 4219472..4219750 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
EL024_RS21045 4219762..4221075 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4205737..4224990 19253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T286601 WP_001054376.1 NZ_LR134031:4215952-4216209 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19974.91 Da        Isoelectric Point: 6.3277

>AT286601 WP_001350781.1 NZ_LR134031:4216221-4216766 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References