Detailed information of TA system TA028660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 3422017..3422485
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L0DZD4
• Locus tag: TVNIR_RS15645
• Protein ID: WP_015260043.1
• Coordinates: 3422017..3422289 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: TVNIR_RS15650
• Protein ID: WP_043739829.1
• Coordinates: 3422273..3422485 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS15605	3417892..3418362	-	471	WP_015260033.1	helix-turn-helix domain-containing protein	-
TVNIR_RS15610	3418548..3419014	-	467	Protein_3136	DUF5131 family protein	-
TVNIR_RS15615	3419127..3419417	-	291	WP_015260036.1	nucleotidyltransferase	-
TVNIR_RS15620	3419651..3420046	-	396	WP_015260038.1	hypothetical protein	-
TVNIR_RS15625	3420121..3420426	-	306	WP_015260039.1	nucleotidyltransferase domain-containing protein	-
TVNIR_RS15630	3420612..3420809	-	198	WP_015260040.1	DUF2283 domain-containing protein	-
TVNIR_RS15635	3421447..3421782	+	336	WP_043739827.1	helix-turn-helix transcriptional regulator	-
TVNIR_RS15640	3421775..3422020	+	246	WP_015260042.1	HipA N-terminal domain-containing protein	-
TVNIR_RS15645	3422017..3422289	-	273	WP_015260043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TVNIR_RS15650	3422273..3422485	-	213	WP_043739829.1	ribbon-helix-helix domain-containing protein	Antitoxin
TVNIR_RS15655	3422753..3423079	-	327	WP_043739830.1	type II toxin-antitoxin system RelE/ParE family toxin	-
TVNIR_RS15660	3423088..3423351	-	264	WP_015260046.1	ribbon-helix-helix domain-containing protein	-
TVNIR_RS15665	3423594..3423791	-	198	WP_015260047.1	DUF2283 domain-containing protein	-
TVNIR_RS15670	3423909..3424517	-	609	WP_015260048.1	plasmid pRiA4b ORF-3 family protein	-
TVNIR_RS15675	3424633..3424842	-	210	WP_052316649.1	nucleotidyltransferase family protein	-
TVNIR_RS15685	3425264..3425497	+	234	Protein_3150	cupin domain-containing protein	-
TVNIR_RS15690	3425601..3426165	-	565	Protein_3151	PIN domain-containing protein	-
TVNIR_RS15695	3426165..3426617	-	453	WP_043739833.1	helix-turn-helix domain-containing protein	-
TVNIR_RS15700	3426842..3427267	-	426	WP_015260052.1	YchJ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3395529..3423079	27550

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (4-38)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10788.45 Da
• Isoelectric Point: 9.9040

>T28660 WP_015260043.1 NC_019902:c3422289-3422017 [Thioalkalivibrio nitratireducens DSM 14787]
MAWNVEFIDTARRQLARLDRKWQAAILDYLEDEIAPLDDPRSRGKPLVGDRKGLWRYRVGDYRILCELQDNHLIVLVVTI
GHRREVYRKR

Nucleotide

• Length: 273 bp

>T28660 NC_019902:c3422289-3422017 [Thioalkalivibrio nitratireducens DSM 14787]
TTGGCCTGGAACGTTGAGTTCATCGATACGGCCAGGCGTCAACTGGCCAGGCTCGACAGGAAGTGGCAGGCCGCCATCCT
CGATTACCTCGAAGACGAGATCGCACCCCTTGACGATCCGCGCAGTCGCGGCAAGCCGCTCGTAGGCGACAGAAAGGGGC
TTTGGCGCTATCGCGTTGGGGATTACCGCATCCTCTGCGAGCTACAGGACAACCACCTGATCGTCCTCGTGGTGACCATT
GGGCATCGGCGCGAGGTCTATCGGAAGCGTTAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7967.15 Da
• Isoelectric Point: 5.1369

>AT28660 WP_043739829.1 NC_019902:c3422485-3422273 [Thioalkalivibrio nitratireducens DSM 14787]
MLAVRLDPQMEKELEQLAAATGRSKSYYVKEALAAYLEDRADYLLALAALERKEPRTSLADVRRELGLER

Nucleotide

• Length: 213 bp

>AT28660 NC_019902:c3422485-3422273 [Thioalkalivibrio nitratireducens DSM 14787]
ATGCTCGCTGTGAGACTCGACCCGCAAATGGAGAAGGAGCTTGAACAGCTCGCCGCCGCTACAGGGCGCAGCAAGAGCTA
CTACGTGAAGGAGGCGCTTGCCGCGTACCTCGAGGACCGCGCCGACTACCTGCTGGCGCTCGCCGCCCTGGAGCGGAAGG
AACCGCGCACGAGCCTGGCGGACGTGAGACGCGAGCTTGGCCTGGAACGTTGA

Structures

Toxin

• AlphaFold DB: L0DZD4