Detailed information of TA system TA028658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE(toxin)
• Location: 2925505..2926076
• Replicon: chromosome
• Accession: NC_019902
• Organism: Thioalkalivibrio nitratireducens DSM 14787

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TVNIR_RS13405
• Protein ID: WP_043740674.1
• Coordinates: 2925505..2925789 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: L0E1H4
• Locus tag: TVNIR_RS13410
• Protein ID: WP_015259582.1
• Coordinates: 2925789..2926076 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TVNIR_RS13395	2920551..2924663	+	4113	WP_015259578.1	DEAD/DEAH box helicase	-
TVNIR_RS13400	2924851..2925153	-	303	WP_015259579.1	CopG family transcriptional regulator	-
TVNIR_RS19835	2925269..2925367	+	99	Protein_2690	ATP-binding protein	-
TVNIR_RS13405	2925505..2925789	-	285	WP_043740674.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
TVNIR_RS13410	2925789..2926076	-	288	WP_015259582.1	hypothetical protein	Antitoxin
TVNIR_RS19840	2926337..2926688	-	352	Protein_2693	IS110 family transposase	-
TVNIR_RS13415	2927601..2927849	-	249	Protein_2694	ATP-binding protein	-
TVNIR_RS13420	2927864..2928109	+	246	Protein_2695	ATP-binding protein	-
TVNIR_RS13425	2928716..2929594	+	879	WP_015259588.1	DUF4338 domain-containing protein	-
TVNIR_RS13430	2929591..2930973	+	1383	WP_015259589.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10745.27 Da
• Isoelectric Point: 4.8261

>T28658 WP_043740674.1 NC_019902:c2925789-2925505 [Thioalkalivibrio nitratireducens DSM 14787]
MELFWTPEAIQDRDAIYDFIDADNPVAALALDELFEEKTGRLVDHPDLGRPGRIVGTRELVVHRNYVLVYDVPGDLVRVL
RVLHAARQWPPVRG

Nucleotide

• Length: 285 bp

>T28658 NC_019902:c2925789-2925505 [Thioalkalivibrio nitratireducens DSM 14787]
ATGGAGCTGTTCTGGACGCCAGAGGCGATACAAGACCGCGACGCAATCTATGACTTCATCGATGCCGACAACCCGGTCGC
CGCGCTGGCCCTCGATGAGCTGTTTGAAGAGAAGACCGGACGCCTGGTCGATCATCCCGACCTTGGTCGGCCGGGCCGCA
TCGTCGGCACGCGCGAGCTGGTCGTGCACCGGAATTATGTTCTGGTCTATGACGTACCCGGCGACTTGGTGCGCGTGCTG
CGCGTCCTGCACGCGGCCAGGCAGTGGCCACCAGTTCGTGGGTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10918.25 Da
• Isoelectric Point: 10.3390

>AT28658 WP_015259582.1 NC_019902:c2926076-2925789 [Thioalkalivibrio nitratireducens DSM 14787]
MSEVTFTFRVDETLKSQFATAAKERDRTGAQLLRDFMREFVRQQQEATEHDAWYRRQVQIGLDSANAGNLTPAAEVEAKF
AAKRAATRRRLEPTK

Nucleotide

• Length: 288 bp

>AT28658 NC_019902:c2926076-2925789 [Thioalkalivibrio nitratireducens DSM 14787]
ATGAGCGAAGTCACTTTCACCTTCCGGGTCGATGAGACCCTGAAAAGCCAATTCGCCACGGCCGCGAAGGAACGCGACCG
TACCGGCGCGCAGCTCCTGCGCGATTTTATGCGCGAGTTCGTGCGGCAGCAACAGGAGGCCACAGAGCATGACGCCTGGT
ACCGTCGCCAGGTGCAAATCGGCCTGGATTCAGCCAACGCCGGCAACCTGACCCCGGCGGCCGAAGTCGAAGCCAAGTTC
GCGGCAAAGCGGGCAGCAACGCGCCGCCGGCTTGAACCCACGAAATGA

Structures

Antitoxin

• AlphaFold DB: L0E1H4