Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4003777..4004611 Replicon chromosome
Accession NZ_LR134000
Organism Escherichia coli strain NCTC9066

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1J6XFW9
Locus tag EL014_RS19510 Protein ID WP_000854770.1
Coordinates 4003777..4004154 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL014_RS19515 Protein ID WP_001332042.1
Coordinates 4004243..4004611 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL014_RS19475 3999405..4000151 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
EL014_RS19480 4000166..4001707 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
EL014_RS19490 4002301..4002477 - 177 Protein_3774 helix-turn-helix domain-containing protein -
EL014_RS22670 4002841..4002999 - 159 WP_001467148.1 hypothetical protein -
EL014_RS19500 4003099..4003275 - 177 WP_000839286.1 DUF957 domain-containing protein -
EL014_RS19505 4003292..4003780 - 489 WP_000761690.1 hypothetical protein -
EL014_RS19510 4003777..4004154 - 378 WP_000854770.1 TA system toxin CbtA family protein Toxin
EL014_RS19515 4004243..4004611 - 369 WP_001332042.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL014_RS19520 4004774..4004995 - 222 WP_000692323.1 DUF987 domain-containing protein -
EL014_RS19525 4005058..4005534 - 477 WP_001186779.1 RadC family protein -
EL014_RS19530 4005550..4006014 - 465 WP_000855061.1 antirestriction protein -
EL014_RS19540 4006356..4007174 - 819 WP_126315351.1 DUF945 domain-containing protein -
EL014_RS19550 4007329..4007487 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14196.37 Da        Isoelectric Point: 8.7438

>T286577 WP_000854770.1 NZ_LR134000:c4004154-4003777 [Escherichia coli]
MKTLPDTHVRKVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13677.38 Da        Isoelectric Point: 6.5931

>AT286577 WP_001332042.1 NZ_LR134000:c4004611-4004243 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAFYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6XFW9

Antitoxin

Source ID Structure

References